Document Detail

Effects of prostaglandins and endoperoxide analogs on canine saphenous vein.
MedLine Citation:
PMID:  910924     Owner:  NLM     Status:  MEDLINE    
Contractile effects of prostaglandins (PGs) have not been widely studied in the canine saphenous vein, as in vitro model for venous function. We studied responses to two PG endoperoxide analogs (PGEA) and to monoenoic and bisenoic PGs of the A, B, E, and F series in helical strips of canine saphenous veins. Isometric changes in force were measured. All agents elicited marked contractions. PGEA were several orders of magnitude more potent than either primary PGs or other venoconstrictors, including norepinephrine. E- and A-types PG had unusual concentration and contraction at high concentration. B-types PG evoked a biphasic contractile response. Bisenoic PGs tended to be more potent than monoenoic PGs of the same type. These results show that canine saphenous veins are highly responsive to PGs and PGEA. These data suggest that these substances could influence venous tone in vivo. However, PG-induced changes in venous tone would depend on which PG or intermediate was present, on PG concentration, and on the prior state of venous tone.
M R Goldberg; V S Hebert; P J Kadowitz
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  233     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-11-30     Completed Date:  1977-11-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H361-8     Citation Subset:  IM    
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MeSH Terms
Arachidonic Acids / pharmacology
Dose-Response Relationship, Drug
Muscle Contraction
Norepinephrine / pharmacology
Prostaglandin Endoperoxides, Synthetic / pharmacology*
Prostaglandins / pharmacology*
Prostaglandins A / pharmacology
Prostaglandins B / pharmacology
Prostaglandins E / pharmacology
Prostaglandins F / pharmacology
Prostaglandins H / pharmacology
Saphenous Vein / drug effects*,  physiology
Structure-Activity Relationship
Vasoconstriction / drug effects*
Reg. No./Substance:
0/Arachidonic Acids; 0/Prostaglandin Endoperoxides, Synthetic; 0/Prostaglandins; 0/Prostaglandins A; 0/Prostaglandins B; 0/Prostaglandins E; 0/Prostaglandins F; 0/Prostaglandins H; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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