| Effects of prostaglandins and endoperoxide analogs on canine saphenous vein. | |
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MedLine Citation:
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PMID: 910924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Contractile effects of prostaglandins (PGs) have not been widely studied in the canine saphenous vein, as in vitro model for venous function. We studied responses to two PG endoperoxide analogs (PGEA) and to monoenoic and bisenoic PGs of the A, B, E, and F series in helical strips of canine saphenous veins. Isometric changes in force were measured. All agents elicited marked contractions. PGEA were several orders of magnitude more potent than either primary PGs or other venoconstrictors, including norepinephrine. E- and A-types PG had unusual concentration and contraction at high concentration. B-types PG evoked a biphasic contractile response. Bisenoic PGs tended to be more potent than monoenoic PGs of the same type. These results show that canine saphenous veins are highly responsive to PGs and PGEA. These data suggest that these substances could influence venous tone in vivo. However, PG-induced changes in venous tone would depend on which PG or intermediate was present, on PG concentration, and on the prior state of venous tone. |
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Authors:
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M R Goldberg; V S Hebert; P J Kadowitz |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 233 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1977 Sep |
Date Detail:
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Created Date: 1977-11-30 Completed Date: 1977-11-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H361-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acids / pharmacology Dogs Dose-Response Relationship, Drug Muscle Contraction Norepinephrine / pharmacology Prostaglandin Endoperoxides, Synthetic / pharmacology* Prostaglandins / pharmacology* Prostaglandins A / pharmacology Prostaglandins B / pharmacology Prostaglandins E / pharmacology Prostaglandins F / pharmacology Prostaglandins H / pharmacology Saphenous Vein / drug effects*, physiology Structure-Activity Relationship Vasoconstriction / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Prostaglandin Endoperoxides, Synthetic; 0/Prostaglandins; 0/Prostaglandins A; 0/Prostaglandins B; 0/Prostaglandins E; 0/Prostaglandins F; 0/Prostaglandins H; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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