| Effects of prostaglandins on cyclic nucleotide phosphodiesterase activity in the human term placenta. | |
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MedLine Citation:
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PMID: 6289380 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Slices of human full-term placentas, obtained by elective cesarean section, were incubated in the absence or presence of prostaglandins (PGs) and the cyclic AMP phosphodiesterase (cAMP PDE) activity was measured. PGE1 and PGI2 were shown to stimulate cAMP PDE activity. The effect of PGE1 is related to an increase in the Vmax of the low Km activity without alteration of this apparent Km. Several findings suggest that the cAMP PDE is activated by its own substrate; PGE1 and PGI2, promote an increase of cAMP formation which is observed before the cAMP PDE activation. Dibutyryl cAMP or theophylline also activate cAMP PDE. In contrast, PGF2 alpha does not influence either adenylate cyclase or AMP PDE. In addition, we found that the ability of the placenta to degrade cAMP, increases after parturition. PG levels are higher in the foeto-placental unit during labor, and a causal relationship between these two phenomena is possible. Our data supporting the concept of hormonal control of cAMP PDE is consistent with the hypothesis that an accelerated cAMP metabolism in placenta contributes to the maintenance of a constant equilibrium of the cyclic nucleotide levels in the foeto-placental unit. |
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Authors:
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F Ferre; M Breuiller; L Cedard |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prostaglandins Volume: 23 ISSN: 0090-6980 ISO Abbreviation: Prostaglandins Publication Date: 1982 May |
Date Detail:
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Created Date: 1982-12-02 Completed Date: 1982-12-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0320271 Medline TA: Prostaglandins Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 675-93 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3',5'-Cyclic-AMP Phosphodiesterases
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metabolism* Alprostadil Cyclic AMP / metabolism Cyclic GMP / metabolism Dose-Response Relationship, Drug Epinephrine / pharmacology Epoprostenol / pharmacology* Female Humans Kinetics Placenta / drug effects, enzymology* Pregnancy Prostaglandins / pharmacology* Prostaglandins E / pharmacology* Theophylline / pharmacology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins; 0/Prostaglandins E; 35121-78-9/Epoprostenol; 51-43-4/Epinephrine; 58-55-9/Theophylline; 60-92-4/Cyclic AMP; 745-65-3/Alprostadil; 7665-99-8/Cyclic GMP; EC 3.1.4.17/3',5'-Cyclic-AMP Phosphodiesterases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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