Document Detail


Effects of prostaglandin inhibition on the renal function curve during ovine pregnancy.
MedLine Citation:
PMID:  8092204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This study was designed to assess the influence of prostaglandins on the steady-state relationship of mean arterial pressure and urinary sodium excretion. STUDY DESIGN: Ten nonpregnant and nine pregnant ewes were chronically prepared with indwelling catheters and maintained in metabolism cages. All the ewes received a continuous intravenous infusion of indomethacin (5 mg/kg/day) for 24 days. Step increases in sodium intake (20, 100, 400, and 1200 mmol per day), each maintained for 6 days, were administered as a fixed dietary (20 mmol) component with the balance infused intravenously. Mean arterial pressure was continuously monitored. The renal function curves were constructed from the steady-state mean arterial pressure-urinary sodium excretion relationships after sodium balance was attained. RESULTS: Indomethacin inhibited urinary excretion of prostaglandin E2 by 62% +/- 4% in nonpregnant and 47% +/- 6% in pregnant ewes, and 6 keto-prostaglandin F1 alpha, the stable metabolite of prostaglandin I2, by 55% +/- 4% and 65% +/- 6% in nonpregnant and pregnant ewes, respectively. Blood volume was not affected by indomethacin or salt in either group. Plasma angiotensin II was suppressed less in pregnant ewes (60% vs 80%) by increases in salt intake. Chronic treatment with indomethacin did not alter the renal function curves of either nonpregnant or pregnant ewes. CONCLUSIONS: These results suggest that prostaglandins do not influence the steady-state relationship between mean arterial pressure and urinary sodium excretion in either nonpregnant or pregnant sheep.
Authors:
S Mukaddam-Daher; J M Moutquin; J Gutkowska; B S Nuwayhid; E W Quillen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  171     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-10-18     Completed Date:  1994-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  599-607     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, McGill University, Montreal, Canada.
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MeSH Terms
Descriptor/Qualifier:
6-Ketoprostaglandin F1 alpha / urine
Analysis of Variance
Angiotensin II / blood
Animals
Blood Pressure / drug effects
Dinoprostone / urine
Female
Indomethacin / pharmacology*
Kidney / drug effects*,  metabolism,  physiology
Natriuresis / drug effects
Pregnancy
Pregnancy, Animal / drug effects*,  metabolism,  physiology
Prostaglandins / biosynthesis,  physiology*
Sheep
Sodium / urine
Sodium, Dietary / administration & dosage
Chemical
Reg. No./Substance:
0/Prostaglandins; 0/Sodium, Dietary; 11128-99-7/Angiotensin II; 363-24-6/Dinoprostone; 53-86-1/Indomethacin; 58962-34-8/6-Ketoprostaglandin F1 alpha; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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