| Effects of prostaglandin F(2α) analogues on endothelin-1-induced impairment of rabbit ocular blood flow: comparison among tafluprost, travoprost, and latanoprost. | |
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MedLine Citation:
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PMID: 20868682 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the effects of prostaglandin F(2α) (PGF(2α)) analogues on the endothelin-1 (ET-1)-induced impairment of optic nerve head (ONH) blood flow and on ET-1-induced contraction in isolated ciliary artery segments. In male rabbits, one of four PGF(2α) analogues [0.0015% tafluprost, 0.0015% 15-hydroxyl tafluprost (15-OH tafluprost), 0.005% latanoprost, or 0.004% travoprost] was topically administered at various pretreatment times before intravitreal ET-1 injection. ONH blood flow was estimated by the laser speckle method, which expresses blood velocity as a quantitative index, the squared blur rate (SBR). SBR was measured just before (baseline value) and at 30, 60, and 120 min after ET-1 injection. SBR was significantly decreased from 4.47 ± 0.20 to 3.50 ± 0.10 (78.6 ± 2.4% of baseline) at 120 min after intravitreal ET-1 injection (5 pmol/eye). The ET-1-induced decrease was almost completely prevented by tafluprost and significantly inhibited by the other three analogues. The inhibitory effect lasted longest with tafluprost, as indicated by the effective pretreatment times (tafluprost: 90, 120, or 240 min; 15-OH tafluprost: 90, but not 120 or 240 min; latanoprost and travoprost: 120, but not 240 min). In vitro, the effects of PGF(2α) analogues on ET-1-induced contractions in male rabbit ciliary arteries were evaluated using an isometric tension recording system. Tafluprost, latanoprost, travoprost, and 15-OH tafluprost concentration-dependently relaxed the 10 nM ET-1-induced ciliary artery contraction. Improvement of the ocular circulation may be superior with tafluprost than with the other PGF(2α) analogues. The underlying mechanism may involve relaxation of ocular resistance vessels. |
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Authors:
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Hiroaki Kurashima; Hiroshi Watabe; Noriko Sato; Sanae Abe; Naruhiro Ishida; Takeshi Yoshitomi |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-09-22 |
Journal Detail:
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Title: Experimental eye research Volume: 91 ISSN: 1096-0007 ISO Abbreviation: Exp. Eye Res. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-29 Completed Date: 2010-12-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370707 Medline TA: Exp Eye Res Country: England |
Other Details:
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Languages: eng Pagination: 853-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Research and Development Center, Santen Pharmaceutical Co. Ltd., Nara, Japan. hiroaki.kurashima@santen.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Animals Antihypertensive Agents / pharmacology* Blood Flow Velocity / drug effects Ciliary Arteries / physiology Cloprostenol / analogs & derivatives*, pharmacology Dinoprost / analogs & derivatives* Endothelin-1 / antagonists & inhibitors*, toxicity Isometric Contraction / drug effects Laser-Doppler Flowmetry Male Muscle, Smooth, Vascular / physiology Optic Disk / blood supply* Prostaglandins F / pharmacology* Prostaglandins F, Synthetic / pharmacology* Rabbits Regional Blood Flow / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Endothelin-1; 0/Prostaglandins F; 0/Prostaglandins F, Synthetic; 0/tafluprost; 130209-82-4/latanoprost; 157283-68-6/travoprost; 40665-92-7/Cloprostenol; 551-11-1/Dinoprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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