Document Detail

Effects of prostaglandin E2 inhalation on hypercapnic response in normal subjects.
MedLine Citation:
PMID:  7952620     Owner:  NLM     Status:  MEDLINE    
It is known that the ventilatory response to carbon dioxide (CO2) is increased in asthmatics with airway obstruction. Increased vagal afferent activity as well as increased airway resistance have been postulated as the causative mechanisms. However, whether increased vagal afferent activity without bronchoconstriction increases the ventilatory response to CO2 has not been investigated in humans. We examined the effects of prostaglandin E2 (PGE2) inhalation, which is known to stimulate vagal afferent receptors in the lung without an increase in airway resistance, on the respiratory response to CO2 in seven healthy male subjects. Either physiologic saline or PGE2 (100 micrograms/ml) was inhaled through a Bird nebulizer for 3 min. Twenty minutes after each inhalation, the responses of minute ventilation (VE) and occlusion pressure (P0.1) to hyperoxic hypercapnia were measured. Both the relationships between VE and P0.1 to an increase in tension of end-tidal CO2 (PETCO2) were analyzed by linear regression. Although the mean value of respiratory resistance after PGE2 (3.0 cm H2O/L/s +/- 0.4) did not differ significantly from that after saline (3.1 cm H2O/L/s +/- 0.4), inhaled PGE2 significantly increased the hypercapnic response. This result suggests that the increased vagal afferent activity per se plays an important role in increasing the hypercapnic ventilatory response in humans.
J Midorikawa; Y Kikuchi; O Taguchi; W Hida; S Okabe; T Takishima; K Shirato
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  150     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1994-12-28     Completed Date:  1994-12-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1592-7     Citation Subset:  AIM; IM; S    
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
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MeSH Terms
Administration, Inhalation
Dinoprostone / administration & dosage*
Drug Evaluation
Forced Expiratory Volume / drug effects
Hypercapnia / drug therapy*,  physiopathology
Least-Squares Analysis
Reference Values
Time Factors
Vital Capacity / drug effects
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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