| Effects of prostaglandin E2 inhalation on hypercapnic response in normal subjects. | |
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MedLine Citation:
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PMID: 7952620 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is known that the ventilatory response to carbon dioxide (CO2) is increased in asthmatics with airway obstruction. Increased vagal afferent activity as well as increased airway resistance have been postulated as the causative mechanisms. However, whether increased vagal afferent activity without bronchoconstriction increases the ventilatory response to CO2 has not been investigated in humans. We examined the effects of prostaglandin E2 (PGE2) inhalation, which is known to stimulate vagal afferent receptors in the lung without an increase in airway resistance, on the respiratory response to CO2 in seven healthy male subjects. Either physiologic saline or PGE2 (100 micrograms/ml) was inhaled through a Bird nebulizer for 3 min. Twenty minutes after each inhalation, the responses of minute ventilation (VE) and occlusion pressure (P0.1) to hyperoxic hypercapnia were measured. Both the relationships between VE and P0.1 to an increase in tension of end-tidal CO2 (PETCO2) were analyzed by linear regression. Although the mean value of respiratory resistance after PGE2 (3.0 cm H2O/L/s +/- 0.4) did not differ significantly from that after saline (3.1 cm H2O/L/s +/- 0.4), inhaled PGE2 significantly increased the hypercapnic response. This result suggests that the increased vagal afferent activity per se plays an important role in increasing the hypercapnic ventilatory response in humans. |
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Authors:
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J Midorikawa; Y Kikuchi; O Taguchi; W Hida; S Okabe; T Takishima; K Shirato |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 150 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1994-12-28 Completed Date: 1994-12-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1592-7 Citation Subset: AIM; IM; S |
Affiliation:
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First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Dinoprostone / administration & dosage* Drug Evaluation Forced Expiratory Volume / drug effects Humans Hypercapnia / drug therapy*, physiopathology Least-Squares Analysis Male Reference Values Rest Spirometry Time Factors Vital Capacity / drug effects |
| Chemical | |
Reg. No./Substance:
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363-24-6/Dinoprostone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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