| Effects of prostacyclin on spinal cord ischemia: an experimental study. | |
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MedLine Citation:
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PMID: 8356524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Paraplegia after thoracic aortic aneurysm has an incidence of 2.2% to 24%. This study was planned to show the beneficial effects of prostacyclin on spinal cord ischemia. METHODS: Twelve rabbits underwent 30 minutes of aortic occlusion. Six rabbits received prostacyclin, whereas the remaining rabbits did not. Prostacyclin administration was started with a rate of 5 ng/kg/min 5 minutes before aortic occlusion. This dosage was increased to 25 ng/kg/min during aortic occlusion. Prostacyclin administration after aortic occlusion was maintained for a period of 5 minutes. During this period, prostacyclin dosage was 5 ng/kg/min. RESULTS: One rabbit in the prostacyclin group and five rabbits in the control group were paraplegic. Arterial pressure proximal to the clamp was 65 +/- 7 mm Hg before aortic occlusion and 78 +/- 10 mm Hg during aortic occlusion in the control group and 68 +/- 12 mm Hg before aortic occlusion and 65 +/- 6 mm Hg during aortic occlusion in the prostacyclin group. Arterial pressure distal to the clamp was 11 +/- 4 mm Hg during aortic occlusion in the control group and 18 +/- 5 mm Hg during aortic occlusion in the prostacyclin group (p = 0.02). CONCLUSIONS: Intravenous prostacyclin reduced the neurologic injury caused by spinal cord ischemia and reperfusion after 30 minutes of aortic occlusion in the rabbit model. |
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Authors:
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S F Katircio?lu; D S K???kaksu; S K?pl?l?; R Vural; M Bayazit; O Ta?demir; K Bayazit |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Surgery Volume: 114 ISSN: 0039-6060 ISO Abbreviation: Surgery Publication Date: 1993 Jul |
Date Detail:
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Created Date: 1993-09-21 Completed Date: 1993-09-21 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 36-9 Citation Subset: AIM; IM |
Affiliation:
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Cardiovascular Surgery Clinic, T?rkiye Y?ksek Ihtisas Hospital, Ankara. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta Blood Pressure / drug effects Constriction Epoprostenol / pharmacology* Ischemia / etiology, physiopathology* Male Paralysis / etiology Rabbits Reference Values Spinal Cord / blood supply* |
| Chemical | |
Reg. No./Substance:
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35121-78-9/Epoprostenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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