| Effects of prostacyclin and beraprost on ciliary motility of rabbit airway epithelium. | |
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MedLine Citation:
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PMID: 8153147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of prostacyclin and its stable analog beraprost on ciliary beat frequency (CBF) of rabbit tracheal epithelium were studied by a microphoto-oscillation technique in vitro. Addition of these drugs increased CBF in a dose-dependent fashion: the maximal increase from the baseline value and the drug concentration required to produce a half-maximal effect were 13.3 +/- 2.0% (p < 0.05) and 1.8 +/- 0.4 x 10(-7) mol/l for prostacyclin and 30.8 +/- 3.4% (p < 0.001) and 1.6 +/- 0.5 x 10(-7) mol/l for beraprost. These effects were accompanied by the increase in intracellular cyclic AMP levels. Thus, prostacyclin and beraprost may stimulate ciliary motility and, hence, mucociliary transport through the production of cyclic AMP. |
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Authors:
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J Tamaoki; S Sakai; A Chiyotani; K Takeyama; E Tagaya; K Konno |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacology Volume: 48 ISSN: 0031-7012 ISO Abbreviation: Pharmacology Publication Date: 1994 Mar |
Date Detail:
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Created Date: 1994-05-09 Completed Date: 1994-05-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0152016 Medline TA: Pharmacology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 194-200 Citation Subset: IM |
Affiliation:
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First Department of Medicine, Tokyo Women's Medical College, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cilia / drug effects, physiology Cyclic AMP / metabolism Epithelium / drug effects Epoprostenol / analogs & derivatives*, pharmacology*, therapeutic use Male Rabbits Trachea / drug effects* |
| Chemical | |
Reg. No./Substance:
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35121-78-9/Epoprostenol; 60-92-4/Cyclic AMP; 88430-50-6/beraprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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