| Effects of propranolol and indomethacin on muscarinic airway reactivity in unanesthetized guinea pigs. | |
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MedLine Citation:
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PMID: 3006079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate whether endogenous beta-adrenergic stimulation or cyclooxygenase products normally affect muscarinic reactivity in conscious, spontaneously breathing guinea pigs, we measured specific airway resistance (SRaw) during acetylcholine (ACh) infusion before and after treatment with propranolol (10 mg/kg ip) or indomethacin (30 mg/kg ip). Airway reactivity was assessed by measuring changes in SRaw upon increasing ACh infusion. We found that propranolol treatment increased reactivity to parenteral ACh, but did not change baseline SRaw. Furthermore, propranolol reduced the range in muscarinic reactivity for the group, and it enhanced thr reproducibility of measurements in individual animals. In contrast, indomethacin had no effect on either baseline SRaw or muscarinic reactivity. Our results suggest that beta-blockade of endogenous adrenergic stimulation increases the muscarinic reactivity of guinea pig airways, but does not influence resting airway tone. It appears that propranolol treatment allows a more reproducible assessment of muscarinic reactivity in the guinea pig. In contrast, cyclooxygenase products do not seem to significantly affect baseline airway resistance, reactivity, or reproducibility in the guinea pig. |
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Authors:
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J H Roum; C G Murlas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) Volume: 181 ISSN: 0037-9727 ISO Abbreviation: Proc. Soc. Exp. Biol. Med. Publication Date: 1986 Apr |
Date Detail:
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Created Date: 1986-04-18 Completed Date: 1986-04-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7505892 Medline TA: Proc Soc Exp Biol Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 569-74 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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metabolism Airway Resistance / drug effects* Animals Dose-Response Relationship, Drug Guinea Pigs Indomethacin / pharmacology* Male Propranolol / pharmacology* Prostaglandin-Endoperoxide Synthases / metabolism Receptors, Adrenergic, beta / metabolism Receptors, Muscarinic / metabolism* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL-01535/HL/NHLBI NIH HHS; HL-34228/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic, beta; 0/Receptors, Muscarinic; 51-84-3/Acetylcholine; 525-66-6/Propranolol; 53-86-1/Indomethacin; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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