Document Detail


Effects of propranolol during pregnancy and development of rats. I. Adverse effects during pregnancy.
MedLine Citation:
PMID:  693116     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnant rats, treated with high doses of propranolol, gave birth to small for dates neonates. Litter size was affected in daily doses of 100 and 150 mg/kg/day. Propranolol markedly influenced the gain in weight normally observed in pregnant rats. The placentas of the rats which received the higher doses of propranolol weighed about 30% less than normal placentas. Pregnant rats, treated with propranolol, gave birth to small for dates neonates. This effect is possibly the result of a drug-induced reduction in transport across cellular membranes, resulting in malnutrition. Since similar effects were reported in humans, treatment with propranolol during pregnancy should be further reevaluated in laboratory animals.
Authors:
N Schoenfeld; O Epstein; L Nemesh; M Rosen; A Atsmon
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  12     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1978 Jul 
Date Detail:
Created Date:  1978-11-22     Completed Date:  1978-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  747-50     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Birth Weight / drug effects
Body Weight / drug effects
Dose-Response Relationship, Drug
Female
Fetus / drug effects*
Placenta / drug effects
Pregnancy
Pregnancy, Animal / drug effects*
Propranolol / toxicity*
Rats
Chemical
Reg. No./Substance:
525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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