| Effects of propranolol during pregnancy and development of rats. I. Adverse effects during pregnancy. | |
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MedLine Citation:
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PMID: 693116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pregnant rats, treated with high doses of propranolol, gave birth to small for dates neonates. Litter size was affected in daily doses of 100 and 150 mg/kg/day. Propranolol markedly influenced the gain in weight normally observed in pregnant rats. The placentas of the rats which received the higher doses of propranolol weighed about 30% less than normal placentas. Pregnant rats, treated with propranolol, gave birth to small for dates neonates. This effect is possibly the result of a drug-induced reduction in transport across cellular membranes, resulting in malnutrition. Since similar effects were reported in humans, treatment with propranolol during pregnancy should be further reevaluated in laboratory animals. |
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Authors:
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N Schoenfeld; O Epstein; L Nemesh; M Rosen; A Atsmon |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Pediatric research Volume: 12 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 1978 Jul |
Date Detail:
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Created Date: 1978-11-22 Completed Date: 1978-11-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 747-50 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Birth Weight / drug effects Body Weight / drug effects Dose-Response Relationship, Drug Female Fetus / drug effects* Placenta / drug effects Pregnancy Pregnancy, Animal / drug effects* Propranolol / toxicity* Rats |
| Chemical | |
Reg. No./Substance:
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525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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