| Effects of propranolol and diltiazem on the rate of high-energy phosphate metabolism in reperfused rat hearts--31P-NMR saturation transfer study. | |
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MedLine Citation:
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PMID: 8340999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relationships between pressure rate product (PRP) and flux (PCr-->ATP) or flux (Pi-->ATP) were studied in isolated perfused rat hearts by the saturation transfer method using 31P-NMR. The effects of propranolol and diltiazem on phosphate metabolism were also studied. After a 40 min preischemic period, the hearts were subjected to a 15 min period of ischemia, followed by 60 min of reperfusion. Propranolol (0.4-1.2 microM) or diltiazem (3.0-6.0 microM) was infused for 30 min before ischemia and reinfused after reperfusion for 60 min. The flux (PCr-->ATP)/PRP ratio at reperfusion did not differ from that at preischemia. This value was also not affected by propranolol or diltiazem treatment. However, the flux (Pi-->ATP)/PRP ratio at reperfusion was significantly less than that at preischemia. Moreover, this value was significantly improved by propranolol or diltiazem treatment. This study demonstrates that 1) flux (PCr-->ATP) has a good correlation with cardiac performance, 2) stunned myocardium needs less ATP turnover for survival of its depressed contractile activity, and 3) flux (Pi-->ATP) can limit recovery of postischemic performance. Protective effects of propranolol and diltiazem are exerted on the flux (Pi-->ATP), i.e. ATP derived from glycolytic flux, in the reperfused heart. |
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Authors:
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Y Okayama; A Kobayashi; Y Fujise; N Yamazaki |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Japanese circulation journal Volume: 57 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 1993 Jun |
Date Detail:
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Created Date: 1993-08-27 Completed Date: 1993-08-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 521-32 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, Hamamatsu University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diltiazem / pharmacology* Heart / drug effects* Magnetic Resonance Spectroscopy / diagnostic use Male Models, Theoretical Myocardium / metabolism* Phosphates / metabolism* Phosphorus Radioisotopes Propranolol / pharmacology* Rats Rats, Wistar Reperfusion |
| Chemical | |
Reg. No./Substance:
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0/Phosphates; 0/Phosphorus Radioisotopes; 42399-41-7/Diltiazem; 525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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