Document Detail

Effects of propranolol and diltiazem on the rate of high-energy phosphate metabolism in reperfused rat hearts--31P-NMR saturation transfer study.
MedLine Citation:
PMID:  8340999     Owner:  NLM     Status:  MEDLINE    
The relationships between pressure rate product (PRP) and flux (PCr-->ATP) or flux (Pi-->ATP) were studied in isolated perfused rat hearts by the saturation transfer method using 31P-NMR. The effects of propranolol and diltiazem on phosphate metabolism were also studied. After a 40 min preischemic period, the hearts were subjected to a 15 min period of ischemia, followed by 60 min of reperfusion. Propranolol (0.4-1.2 microM) or diltiazem (3.0-6.0 microM) was infused for 30 min before ischemia and reinfused after reperfusion for 60 min. The flux (PCr-->ATP)/PRP ratio at reperfusion did not differ from that at preischemia. This value was also not affected by propranolol or diltiazem treatment. However, the flux (Pi-->ATP)/PRP ratio at reperfusion was significantly less than that at preischemia. Moreover, this value was significantly improved by propranolol or diltiazem treatment. This study demonstrates that 1) flux (PCr-->ATP) has a good correlation with cardiac performance, 2) stunned myocardium needs less ATP turnover for survival of its depressed contractile activity, and 3) flux (Pi-->ATP) can limit recovery of postischemic performance. Protective effects of propranolol and diltiazem are exerted on the flux (Pi-->ATP), i.e. ATP derived from glycolytic flux, in the reperfused heart.
Y Okayama; A Kobayashi; Y Fujise; N Yamazaki
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  57     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-08-27     Completed Date:  1993-08-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  521-32     Citation Subset:  IM    
Third Department of Internal Medicine, Hamamatsu University School of Medicine, Japan.
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MeSH Terms
Diltiazem / pharmacology*
Heart / drug effects*
Magnetic Resonance Spectroscopy / diagnostic use
Models, Theoretical
Myocardium / metabolism*
Phosphates / metabolism*
Phosphorus Radioisotopes
Propranolol / pharmacology*
Rats, Wistar
Reg. No./Substance:
0/Phosphates; 0/Phosphorus Radioisotopes; 42399-41-7/Diltiazem; 525-66-6/Propranolol

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