Document Detail


Effects of propranolol and diltiazem on carnitine derivatives and acyl CoA in ischemic myocardium.
MedLine Citation:
PMID:  4094037     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The accumulation of intermediates subsequent to impaired beta-oxidation of free fatty acid (FFA) has been suggested as a cause of cellular damage in ischemic myocardium. We investigated the effects of propranolol and diltiazem on carnitine metabolism in ischemic myocardium. Propranolol (0.2 mg/kg/min, i.v.) and diltiazem (0.1 mg/kg/min, i.v.) were administered for 5 min, the administration started 10 min before coronary occlusion. ECGs were continuously recorded throughout the experiment. Myocardial samples were prepared from both the non-ischemic and ischemic areas 40 min after coronary ligation. Adenosine triphosphate (ATP), free carnitine, long chain acyl carnitine and long chain acyl CoA were assayed. Propranolol reduced the decrease of ATP and the accumulation of long chain acyl CoA, induced by myocardial ischemia. Diltiazem reduced the decrease of ATP and free carnitine, and the accumulation of long chain acyl carnitine in the ischemic area. Propranolol and diltiazem significantly reduced the grade of ventricular arrhythmia. These results suggest that the protective mechanisms of propranolol and diltiazem on myocardium are based, at least in part, on their beneficial effects upon myocardial carnitine metabolism.
Authors:
J Kamiya; A Kobayashi; N Yamazaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  49     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1986-04-10     Completed Date:  1986-04-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1167-74     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acyl Coenzyme A / metabolism*
Adenosine Triphosphate / metabolism
Animals
Arrhythmias, Cardiac / metabolism
Benzazepines / pharmacology*
Carnitine / metabolism*
Coronary Disease / drug therapy,  metabolism*
Diltiazem / pharmacology*
Dogs
Female
Male
Myocardium / metabolism*
Oxidation-Reduction
Propranolol / pharmacology*
Chemical
Reg. No./Substance:
0/Acyl Coenzyme A; 0/Benzazepines; 42399-41-7/Diltiazem; 525-66-6/Propranolol; 541-15-1/Carnitine; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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