| Effects of propranolol on coronary vasculature and cardiac performance in dogs with fixed and dynamic coronary stenosis. | |
| | |
MedLine Citation:
|
PMID: 2632837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The coronary hemodynamic effects of propranolol (0.1 mg/kg, i.v.) were examined in anesthetized dogs with flow-limiting dynamic and fixed coronary stenosis of the left circumflex coronary artery. During fixed coronary stenosis created by external application of an occluder device, propranolol significantly decreased coronary blood flow (CBF) by 6.8 +/- 2.7% (mean +/- SEM, p less than 0.05) and increased mean distal coronary pressure (DCP) by 7 +/- 2.1 mmHg (p less than 0.05). This resulted in a decrease in stenosis resistance (SR) by 26 +/- 3.1% (p less than 0.01) due to oxygen demand reduction. By contrast, during dynamic coronary stenosis produced by an intraluminal microballoon occluder, propranolol decreased CBF by 68 +/- 3.4% (p less than 0.01) and mean DCP by 36 +/- 4.2 mmHg (p less than 0.01), resulting in an increase in SR by 694 +/- 109% (p less than 0.01). This increase in SR was attenuated by pretreatment with an alpha-adrenergic receptor antagonist phentolamine (0.5 mg/kg, i.v.), or by holding heart rate constant at the pretreatment level. These results suggest that propranolol ameliorated the severity of stenosis during fixed coronary stenosis and exacerbated the severity during dynamic coronary stenosis. This increase in SR appears to be related to vasoconstriction of the large stenosed coronary artery, mediated both by alpha-adrenergic receptors in the coronary artery and by myocardial oxygen demand reduction. |
| | |
Authors:
|
M Kashiki; M Yokoyama; H Fukuzaki |
Related Documents
:
|
94407 - Increased diastolic time: a possible important factor in the benefical effect of propra... 7038157 - A randomized trial of propranolol in patients with acute myocardial infarction. i. mort... 1225337 - Investigation of the safe withdrawal period for propranolol in patients scheduled for o... 2968237 - Thyroxine-induced cardiac hypertrophy: time course of development and inhibition by pro... 2733537 - Laser recanalization of pyloric stenosis: a guidewire-directed contact probe technique. 8764527 - Prevalence of myocardial ischemia as depicted by regional wall motion abnormality in bl... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Japanese heart journal Volume: 30 ISSN: 0021-4868 ISO Abbreviation: Jpn Heart J Publication Date: 1989 Nov |
Date Detail:
|
Created Date: 1990-05-11 Completed Date: 1990-05-11 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0401175 Medline TA: Jpn Heart J Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 853-61 Citation Subset: IM |
Affiliation:
|
First Department of Medicine, Kobe University School of Medicine, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Constriction Coronary Circulation / drug effects Coronary Disease / drug therapy* Coronary Vessels / drug effects* Dogs Hemodynamics / drug effects* Propranolol / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of sodium intake on the hypotensive effect of calcium antagonists.
Next Document: Origin of the giant R wave in acute transmural myocardial infarction in the pig.