| Effects of propranolol on cardiopulmonary function in the pony during submaximal exercise. | |
| | |
MedLine Citation:
|
PMID: 3803364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cardiopulmonary responses of four ponies were monitored during standard exercise tests (SET), before and after beta-adrenergic receptor blockade with propranolol. The SET consisted of four 5 min increments of increasing speed from 1.0 to 2.8 m/sec on a treadmill at a 7 degrees incline. Data were collected at rest, throughout the SET and recovery. Administration of propranolol to ponies at rest had no effect on cardiopulmonary function. During the SET, increases in heart rate, mean pulmonary artery flow velocity (an index of cardiac output) and right ventricular dP/dt (an index of myocardial contractility) were progressively attenuated as running speed increased. Body temperature and mean pulmonary artery and right ventricular pressures were significantly elevated over normal. Propranolol treatment had no effect on the responses of mean arterial pressure, haematocrit, haemoglobin, blood lactate and arterial blood gases and pH to the SET. These results suggest that in the pony there is no sympathetic activity to the heart at rest and that during exercise there is pulmonary vasodilation mediated by beta-adrenergic receptors. |
| | |
Authors:
|
W L Sexton; H H Erickson |
Related Documents
:
|
17869044 - Distortion-product otoacoustic emission: early detection in deferoxamine induced ototox... 182504 - Effect of a cholinergic stimulant on interaction of isoprenaline with beta-adrenoceptors. 12355334 - Effect of a long-duration physical exercise on fat cell lipolytic responsiveness to adr... 17463294 - Thermic effect of food and beta-adrenergic thermogenic responsiveness in habitually exe... 1129594 - Effects of nicotine and inhalation of cigarette smoke on total body oxygen consumption ... 1198764 - Segmental ultrasonic test for the study of cholecystodyskinesia. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Equine veterinary journal Volume: 18 ISSN: 0425-1644 ISO Abbreviation: Equine Vet. J. Publication Date: 1986 Nov |
Date Detail:
|
Created Date: 1987-03-17 Completed Date: 1987-03-17 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0173320 Medline TA: Equine Vet J Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 485-9 Citation Subset: IM; S |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Heart / drug effects, physiology* Heart Function Tests / veterinary Horses / physiology* Physical Exertion* Propranolol / pharmacology* Respiration / drug effects* Respiratory Function Tests / veterinary |
| Chemical | |
Reg. No./Substance:
|
525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Glycogen depletion patterns in the muscle of standardbred trotters after exercise of varying intensi...
Next Document: Evaluation of roxithromycin in the treatment of non-gonococcal urethritis in males.