Document Detail


Effects of propranolol on beta-adrenergic receptor of experimental acute myocardial infarction in rats.
MedLine Citation:
PMID:  9812767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
By using receptor autoradiography to observe the distribution and density of receptors, the effects of propranolol, a beta-blocker, on beta-adrenergic receptor of experimental acute myocardial infarction (AMI) were studied. One week after ligation of proximate left anterior descend (LAD) coronary artery, [3H] DHA binding sites were markedly decreased in both infarct region and non-infarct region. After treatment of propranolol (100 micrograms/kg), the [3H] DHA binding sites were obviously increased in the infarct region, and they were further decreased in the non-infarct region. The ratio of [3H] DHA binding sites of the infarct region to non-infarct region was from 0.24 at LAD ligation to 0.87 after propranolol treatment, which was close to 0.97 of control group (sham operation). The results indicated that the propranolol acted directly on myocardial beta- adrenergic through the receptor regulation of the balance of beta-receptors between the infarct region and non-infarct region, and improvement of the myocardial consonation and contraction synergism, thereby protecting the heart affected by AMI.
Authors:
Z Liu; X Liu; J Zhang; X Ouyang; X Guan
Related Documents :
6527977 - Haemodynamic effects of nicardipine in acute myocardial infarction.
2032407 - Electrophysiologic effects of oral diltiazem before and after beta blockade.
991167 - Effects of lignocaine on intramyocardial conduction in nonischaemic and ischaemic canin...
3057847 - The effects of a transtelephonic surveillance and prehospital emergency intervention sy...
8172047 - Adenosine protects against attenuation of flow reserve and myocardial function after co...
2048197 - Demographic and perioperative factors associated with initial and prolonged sinus node ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Tongji Medical University = Tong ji yi ke da xue xue bao     Volume:  17     ISSN:  0257-716X     ISO Abbreviation:  J. Tongji Med. Univ.     Publication Date:  1997  
Date Detail:
Created Date:  1999-02-09     Completed Date:  1999-02-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8605495     Medline TA:  J Tongji Med Univ     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  151-5     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Tongji Hospital, Tongji Medical University, Wuhan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / pharmacology*
Animals
Autoradiography
Female
Male
Myocardial Infarction / metabolism*
Propranolol / pharmacology*
Rats
Rats, Sprague-Dawley
Receptors, Adrenergic, beta / drug effects*,  metabolism
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Receptors, Adrenergic, beta; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reversing effects of DDPH on cardiac hypertrophy and increased collagen content induced by partial n...
Next Document:  Load assessment of the static posture and weight holding in terms of pulmonary ventilation and heart...