Document Detail

Effects of propranolol on beta-adrenergic receptor of experimental acute myocardial infarction in rats.
MedLine Citation:
PMID:  9812767     Owner:  NLM     Status:  MEDLINE    
By using receptor autoradiography to observe the distribution and density of receptors, the effects of propranolol, a beta-blocker, on beta-adrenergic receptor of experimental acute myocardial infarction (AMI) were studied. One week after ligation of proximate left anterior descend (LAD) coronary artery, [3H] DHA binding sites were markedly decreased in both infarct region and non-infarct region. After treatment of propranolol (100 micrograms/kg), the [3H] DHA binding sites were obviously increased in the infarct region, and they were further decreased in the non-infarct region. The ratio of [3H] DHA binding sites of the infarct region to non-infarct region was from 0.24 at LAD ligation to 0.87 after propranolol treatment, which was close to 0.97 of control group (sham operation). The results indicated that the propranolol acted directly on myocardial beta- adrenergic through the receptor regulation of the balance of beta-receptors between the infarct region and non-infarct region, and improvement of the myocardial consonation and contraction synergism, thereby protecting the heart affected by AMI.
Z Liu; X Liu; J Zhang; X Ouyang; X Guan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Tongji Medical University = Tong ji yi ke da xue xue bao     Volume:  17     ISSN:  0257-716X     ISO Abbreviation:  J. Tongji Med. Univ.     Publication Date:  1997  
Date Detail:
Created Date:  1999-02-09     Completed Date:  1999-02-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8605495     Medline TA:  J Tongji Med Univ     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  151-5     Citation Subset:  IM    
Department of Cardiology, Tongji Hospital, Tongji Medical University, Wuhan.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology*
Myocardial Infarction / metabolism*
Propranolol / pharmacology*
Rats, Sprague-Dawley
Receptors, Adrenergic, beta / drug effects*,  metabolism
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Receptors, Adrenergic, beta; 525-66-6/Propranolol

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