Document Detail

Effects of propofol on isolated rabbit mesenteric arteries and veins.
MedLine Citation:
PMID:  7488488     Owner:  NLM     Status:  MEDLINE    
We have investigated the effect of propofol on isolated rabbit mesenteric arteries and veins. Isometric tension was measured in rings of arteries (with or without endothelium) or veins in organ chambers. The preparation was stimulated with noradrenaline 10(-6) mol litre-1, K+ 50 mmol litre-1 and caffeine 20 mmol litre-1 in the presence or absence of propofol. Propofol potentiated noradrenaline-induced contractions at lower concentrations (3 x 10(-5) mol litre-1) and attenuated them at greater concentrations (10(-4) and 3 x 10(-4) mol litre-1) in arteries with endothelium. Propofol inhibited noradrenaline-induced contractions in arteries without endothelium. In contrast, propofol produced venodilatation in a concentration-dependent manner (10(-5) to 3 x 10(-4) mol litre-1) of significantly greater magnitude than that in arteries. Propofol inhibited K+-induced contraction of both arteries and veins. It decreased the relaxation induced by acetylcholine (3 x 10(-8), 10(-7) and 3 x 10(-7) mol litre-1) of noradrenaline-induced contractions of arteries. Propofol did not affect caffeine-induced contractions after pretreatment with increased Ca2+. We conclude that propofol has a more potent vasodilator effect on veins than on arteries. Vasoconstriction induced by propofol may be associated with inhibition of endothelium-derived relaxing factor, whereas vasodilatation induced by propofol may be associated with block of voltage-gated influxes of extracellular Ca2+.
K Kamitani; M Yamazaki; M Yukitaka; Y Ito; Y Momose
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  75     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-01-04     Completed Date:  1996-01-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  457-61     Citation Subset:  IM    
Department of Anaesthesiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
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MeSH Terms
Acetylcholine / antagonists & inhibitors
Anesthetics, Intravenous / pharmacology*
Caffeine / pharmacology
Culture Techniques
Dose-Response Relationship, Drug
Mesenteric Arteries / drug effects*
Mesenteric Veins / drug effects*
Norepinephrine / pharmacology
Potassium / pharmacology
Propofol / pharmacology*
Vasoconstriction / drug effects
Vasodilation / drug effects
Reg. No./Substance:
0/Anesthetics, Intravenous; 2078-54-8/Propofol; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine; 58-08-2/Caffeine; 7440-09-7/Potassium
Comment In:
Br J Anaesth. 1996 Feb;76(2):333-4   [PMID:  8777129 ]

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