Document Detail

Effects of propofol on human microcirculation.
MedLine Citation:
PMID:  18653494     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It is increasingly believed that acute microvascular alterations may be involved in the development of organ dysfunction in critically ill patients. Propofol significantly decreases vascular tone and venous return, which can induce arterial hypotension. However, little is known about the microcirculatory effects of propofol in healthy humans. METHODS: We conducted a prospective, open-labelled trial in 15 patients anaesthetized by propofol for transvaginal oocyte retrieval. The sublingual microcirculatory network was studied before, during, and after propofol infusion using orthogonal polarization spectral imaging. RESULTS: Mean (SD) calculated propofol effect-site concentration was 6.5 (1.8) microg ml(-1). During propofol administration, systemic haemodynamic and oxygenation variables were unchanged, but total microvascular density decreased by 9.1% (P<0.05). The venular density remained unchanged, but the density of perfused capillaries was significantly reduced by 16.7% (P<0.05). Microcirculatory alterations resolved 3 h after discontinuation of the propofol infusion. CONCLUSIONS: Propofol infusion for anaesthesia in man reduces capillary blood flow.
M Koch; D De Backer; J L Vincent; L Barvais; D Hennart; D Schmartz
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2008-07-23
Journal Detail:
Title:  British journal of anaesthesia     Volume:  101     ISSN:  1471-6771     ISO Abbreviation:  Br J Anaesth     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-10     Completed Date:  2008-10-22     Revised Date:  2009-04-14    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  England    
Other Details:
Languages:  eng     Pagination:  473-8     Citation Subset:  IM    
Department of Anaesthesiology, Erasme University Hospital, Université Libre de Bruxelles, Route de Lennik 808, B-1070 Brussels, Belgium.
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MeSH Terms
Anesthetics, Intravenous / pharmacology*
Blood Pressure / drug effects
Capillaries / drug effects,  pathology
Heart Rate / drug effects
Microcirculation / drug effects*
Microscopy, Polarization / methods
Propofol / pharmacology*
Prospective Studies
Tongue / blood supply
Reg. No./Substance:
0/Anesthetics, Intravenous; 2078-54-8/Propofol
Comment In:
Br J Anaesth. 2009 Apr;102(4):561; author reply 561   [PMID:  19286770 ]

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