| Effects of propofol on human microcirculation. | |
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MedLine Citation:
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PMID: 18653494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It is increasingly believed that acute microvascular alterations may be involved in the development of organ dysfunction in critically ill patients. Propofol significantly decreases vascular tone and venous return, which can induce arterial hypotension. However, little is known about the microcirculatory effects of propofol in healthy humans. METHODS: We conducted a prospective, open-labelled trial in 15 patients anaesthetized by propofol for transvaginal oocyte retrieval. The sublingual microcirculatory network was studied before, during, and after propofol infusion using orthogonal polarization spectral imaging. RESULTS: Mean (SD) calculated propofol effect-site concentration was 6.5 (1.8) microg ml(-1). During propofol administration, systemic haemodynamic and oxygenation variables were unchanged, but total microvascular density decreased by 9.1% (P<0.05). The venular density remained unchanged, but the density of perfused capillaries was significantly reduced by 16.7% (P<0.05). Microcirculatory alterations resolved 3 h after discontinuation of the propofol infusion. CONCLUSIONS: Propofol infusion for anaesthesia in man reduces capillary blood flow. |
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Authors:
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M Koch; D De Backer; J L Vincent; L Barvais; D Hennart; D Schmartz |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2008-07-23 |
Journal Detail:
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Title: British journal of anaesthesia Volume: 101 ISSN: 1471-6771 ISO Abbreviation: Br J Anaesth Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-10 Completed Date: 2008-10-22 Revised Date: 2009-04-14 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: England |
Other Details:
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Languages: eng Pagination: 473-8 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology, Erasme University Hospital, Université Libre de Bruxelles, Route de Lennik 808, B-1070 Brussels, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthetics, Intravenous / pharmacology* Blood Pressure / drug effects Capillaries / drug effects, pathology Female Heart Rate / drug effects Humans Microcirculation / drug effects* Microscopy, Polarization / methods Propofol / pharmacology* Prospective Studies Tongue / blood supply |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 2078-54-8/Propofol |
| Comments/Corrections | |
Comment In:
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Br J Anaesth. 2009 Apr;102(4):561; author reply 561
[PMID:
19286770
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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