| Effects of propionyl-L-carnitine in chronically hypoperfused ("hibernating") myocardium. | |
| | |
MedLine Citation:
|
PMID: 1760516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The purpose of this report was to test the effects of systemic treatment with propionyl-L-carnitine in a new model of chronically hypoperfused ("hibernating") myocardium. Adolescent swine were instrumented to undergo a period of mild partial coronary constriction for 1 week (50% reduction of the maximum phasic flow velocity in the anterior descending coronary artery). This reduced regional mechanical function by 56%. The system satisfied criteria defining "hibernating" myocardium, in that the chronic hypoperfusion did not produce massive tissue necrosis and that the reduction in regional contraction remained responsive to inotropic stimulation. Treatment with 50 mg/kg propionyl-L-carnitine by mouth twice daily for 1 week significantly (p less than 0.0005) increased concentrations of free and total carnitine in the myocardial tissue by 39% and 31%, respectively. Treatment with propionyl-L-carnitine did not alter regional systolic shortening in either hibernation or reperfusion for 2 hours, but enhanced one estimate of contractility reserve based on the rate of left ventricular emptying with occlusion of the inferior vena cava. Propionyl-L-carnitine did not reverse the observed impairments in mitochondrial respiration (diminutions in state 3 respiration and the respiratory control ratio), but limited the number of lesions seen on histological examination. Six out of eight placebo hearts showed one or more changes of ischemia, infarction or reperfusion injury, while the same was true in only two out of eight hearts treated with propionyl-L-carnitine (p less than 0.003). Carnitine and various analogues have been proposed to benefit ischemic myocardium. The present data suggest that this general sparing effect may also occur with the propionyl derivative in chronically underperfused myocardium. |
| | |
Authors:
|
H Bolukoglu; A M Eggleston; R Subramanian; S H Nellis; A J Liedtke |
Related Documents
:
|
21951336 - Early cerebral infarction as a risk factor for poor outcome after aneurysmal subarachno... 18719436 - Intraoperative acceleromyographic monitoring reduces the risk of residual neuromuscular... 22403046 - Initial lesion volume is an independent predictor of clinical stroke outcome at day 90:... 242046 - Effect of h+ on force development of the heart muscle under acute respiratory failure b... 8488526 - Risk area and infarct area relations in the hypertensive stroke-prone rat. 8994406 - Atherogenic lipids, vascular dysfunction, and clinical signs of ischemic heart disease. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Cardioscience Volume: 2 ISSN: 1015-5007 ISO Abbreviation: Cardioscience Publication Date: 1991 Dec |
Date Detail:
|
Created Date: 1992-02-13 Completed Date: 1992-02-13 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9014943 Medline TA: Cardioscience Country: ITALY |
Other Details:
|
Languages: eng Pagination: 245-55 Citation Subset: IM |
Affiliation:
|
Section of Cardiology, University of Wisconsin, Madison 53792. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carnitine / analogs & derivatives*, therapeutic use Cell Survival / drug effects Dobutamine / therapeutic use Myocardial Contraction / drug effects* Myocardial Reperfusion Injury / drug therapy*, physiopathology Swine Ventricular Function, Left / drug effects |
| Grant Support | |
ID/Acronym/Agency:
|
HL-32350/HL/NHLBI NIH HHS; HL-41914/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
17298-37-2/propionylcarnitine; 34368-04-2/Dobutamine; 541-15-1/Carnitine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The extracellular matrix in human myocardium: Part I: Collagens I, III, IV, and VI.
Next Document: The efferent mechanisms of reflex hemodynamic responses to distension of the descending colon in ane...