Document Detail


Effects of propionate on mechanical and metabolic performance in aerobic rat hearts.
MedLine Citation:
PMID:  1903299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this report is to describe the contribution of propionate as an adjunct source of oxidative metabolism in aerobic myocardium. In the first series of studies, six groups of isolated working rat hearts (n = 6-8 per group) were perfused for 40 minutes with Krebs-Henseleit media containing 11 mM glucose. Propionate treatment was provided to the media at a constant dose per heart group and extended over a range of dosages, including: 0 (placebo control), 0.1, 0.5, 1.0, 5.0, and 10.0 mM, buffered to pH 7.4. Average aerobic coronary blood flow for all groups was 21.5 +/- 0.6 ml/min; average left ventricular peak systolic pressure was 123.7 +/- 1.4 mmHg. There were no significant differences among groups compared with placebo hearts for aortic flow, heart rate x aortic pressure product, or myocardial oxygen consumption, although performance tended to decline in the 10 mM group. A clear dose-response relationship was observed in 14CO2 production from labeled propionate, with a 12-fold increase between the 0.1 and 10 mM groups. Most of the increase occurred at the lower dosages, with a relative leveling off at the 1.0, 5.0, and 10.0 mM doses. In part 2, propionate was examined as a sole substrate. At 1.0 mM without glucose, propionate per se was unable to support mechanical function over the course of the perfusions, but still maintained high rates of oxidation, comparable to that of the 1.0 mM group with glucose in part 1.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
H Bolukoglu; S H Nellis; A J Liedtke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  5 Suppl 1     ISSN:  0920-3206     ISO Abbreviation:  Cardiovasc Drugs Ther     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-06-27     Completed Date:  1991-06-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  37-43     Citation Subset:  IM    
Affiliation:
Section of Cardiology, University of Wisconsin, Madison.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon Dioxide / metabolism
Dose-Response Relationship, Drug
Heart / drug effects
Hemodynamics / drug effects
Male
Myocardial Contraction / drug effects*
Myocardium / metabolism*
Oxygen Consumption
Propionates / pharmacology*
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
HL 21290/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Propionates; 124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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