Document Detail

Effects of propafenone on function and metabolism in the ischemic working rat heart.
MedLine Citation:
PMID:  1487455     Owner:  NLM     Status:  MEDLINE    
We examined the effects of propafenone, a new anti-dysrhythmic agent, on myocardial function and metabolism in ischemic working rat heart preparations. In the treated hearts, propafenone, 0.3 micrograms/ml and 3 micrograms/ml, were added to Krebs-Henseleit bicarbonate buffer perfusate throughout the experiments. Whole heart ischemia was induced through a one-way aortic valve for 15 min followed by 'reperfusion for 30 min. After induction of ischemia, the cardiac output, peak aortic systolic pressure, left ventricular dP/dtmax, and myocardial ATP concentration were greater in the treated hearts than in the untreated ones. All hearts in the untreated group developed ventricular fibrillation (Vf) at the beginning of the reperfusion period. On the other hand, no treated hearts had Vf at any time during the experiment. However, propafenone, 3 micrograms/ml, evoked a negative inotropic effect before and after ischemia. These results indicate that propafenone may contribute to early recovery from ischemia in myocardial function and metabolism, although it has a negative inotropic action.
T Nakamura; S Kashimoto; T Oguchi; T Kumazawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Heart and vessels     Volume:  7     ISSN:  0910-8327     ISO Abbreviation:  Heart Vessels     Publication Date:  1992  
Date Detail:
Created Date:  1993-02-25     Completed Date:  1993-02-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  169-74     Citation Subset:  IM    
Department of Anesthesiology, Yamanashi Medical College, Japan.
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MeSH Terms
Adenosine Triphosphate / metabolism
Blood Pressure / drug effects,  physiology
Energy Metabolism / drug effects*,  physiology
Heart Rate / drug effects,  physiology
Hemodynamics / drug effects,  physiology
Myocardial Contraction / drug effects*,  physiology
Myocardial Ischemia / physiopathology*
Myocardial Reperfusion Injury / physiopathology
Myocardium / metabolism
Propafenone / pharmacology*
Rats, Wistar
Ventricular Fibrillation / physiopathology*
Reg. No./Substance:
54063-53-5/Propafenone; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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