| Effects of propafenone on function and metabolism in the ischemic working rat heart. | |
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MedLine Citation:
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PMID: 1487455 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the effects of propafenone, a new anti-dysrhythmic agent, on myocardial function and metabolism in ischemic working rat heart preparations. In the treated hearts, propafenone, 0.3 micrograms/ml and 3 micrograms/ml, were added to Krebs-Henseleit bicarbonate buffer perfusate throughout the experiments. Whole heart ischemia was induced through a one-way aortic valve for 15 min followed by 'reperfusion for 30 min. After induction of ischemia, the cardiac output, peak aortic systolic pressure, left ventricular dP/dtmax, and myocardial ATP concentration were greater in the treated hearts than in the untreated ones. All hearts in the untreated group developed ventricular fibrillation (Vf) at the beginning of the reperfusion period. On the other hand, no treated hearts had Vf at any time during the experiment. However, propafenone, 3 micrograms/ml, evoked a negative inotropic effect before and after ischemia. These results indicate that propafenone may contribute to early recovery from ischemia in myocardial function and metabolism, although it has a negative inotropic action. |
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Authors:
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T Nakamura; S Kashimoto; T Oguchi; T Kumazawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Heart and vessels Volume: 7 ISSN: 0910-8327 ISO Abbreviation: Heart Vessels Publication Date: 1992 |
Date Detail:
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Created Date: 1993-02-25 Completed Date: 1993-02-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8511258 Medline TA: Heart Vessels Country: JAPAN |
Other Details:
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Languages: eng Pagination: 169-74 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Yamanashi Medical College, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Blood Pressure / drug effects, physiology Energy Metabolism / drug effects*, physiology Heart Rate / drug effects, physiology Hemodynamics / drug effects, physiology Male Myocardial Contraction / drug effects*, physiology Myocardial Ischemia / physiopathology* Myocardial Reperfusion Injury / physiopathology Myocardium / metabolism Propafenone / pharmacology* Rats Rats, Wistar Ventricular Fibrillation / physiopathology* |
| Chemical | |
Reg. No./Substance:
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54063-53-5/Propafenone; 56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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