| Effects of pronounced weight loss on adiponectin oligomer composition and metabolic parameters. | |
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MedLine Citation:
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PMID: 17495193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Adiponectin is an adipocytokine secreted into circulation in three isoforms. The aim of the study was to investigate changes of adiponectin isoforms during profound weight loss and its relation to anthropomorphometric and metabolic parameters. RESEARCH METHODS AND PROCEDURES: Thirteen severely obese female subjects were examined before and 1 year after surgical treatment. Total adiponectin was determined by radioimmunosorbent assay, and oligomer composition was detected by nondenaturing Western blot. RESULTS: BMI decreased substantially (p < 0.001), which was associated with an increase of total adiponectin from 12.9 +/- 5.9 to 14.3 +/- 6.1 microg/mL (p = 0.055). Medium molecular weight (MMW) adiponectin increased from 7.5 +/- 3.6 to 9.1 +/- 4.1 microg/mL (p = 0.009), whereas high (HMW) and low molecular weight adiponectin remained unchanged. Delta values of total adiponectin correlated significantly with Delta values of anthropometric parameters. Similar correlations were found for Delta values of MMW (Delta weight: r(2) = 0.4132, p = 0.0178; Delta BMI: r(2) = 0.3319, p = 0.0393; Delta fat mass: r(2) = 0.5202, p = 0.0054). DISCUSSION: Thus, profound weight loss was associated with an increase in total adiponectin, which was mainly and consistently caused by increases in MMW adiponectin (p = 0.009). These changes result in a shift from low molecular weight to MMW and HMW adiponectin isoforms, which may be related to improvements in both anthropometric and metabolic parameters. |
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Authors:
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Julia Engl; Thomas Bobbert; Christian Ciardi; Markus Laimer; Tobias Tatarczyk; Susanne Kaser; Helmut Weiss; Clemens Molnar; Herbert Tilg; Josef R Patsch; Joachim Spranger; Christoph F Ebenbichler |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 15 ISSN: 1930-7381 ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-14 Completed Date: 2007-08-06 Revised Date: 2008-01-21 |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 1172-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Clinical Division of General Internal Medicine, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood* Adipose Tissue / anatomy & histology Biological Markers / blood Blood Glucose / metabolism Body Composition Body Mass Index Female Gastric Bypass Humans Lipids / blood Obesity / surgery* Obesity, Morbid / surgery* Protein Isoforms / blood Weight Loss / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Biological Markers; 0/Blood Glucose; 0/Lipids; 0/Protein Isoforms |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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