Document Detail

Effects of prolonging administration gonadotropin on unexpectedly poor ovarian responders undergoing in vitro fertilization.
MedLine Citation:
PMID:  20236519     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There are still some patients who show poor response to ovarian stimulation prior to evidence of normal ovarian reserve in vitro fertilization. However, there are few studies about how to treat the unexpectedly ovarian poor responder in vitro fertilization. The main aim of this study evaluate the effect of prolonging administration follicle-stimulating hormone in woman with the unexpectedly ovarian poor responder in vitro fertilization on implantation rate, clinical pregnancy rate and live birth rate.
METHODS: 922 patients subjected to IVF were divided into two groups according to the predicted criterion of ovarian poor response. 116 patients predicted poor response received the short protocol (group C). The others received the long protocol, among the latter, there were 149 patients undergoing unexpectedly ovarian poor response (group B) and 657 patients exhibited normal ovarian response (group A). The doses of gonadotropin, duration of administration, implantation rate, clinical pregnancy rate and live birth rate were recorded among three groups.
RESULTS: The implantation rate of embryo, clinic pregnancy rate and delivery rate are similar between the group A and group B, while there are significant differences between the doses of gonadotropins (35.1 +/- 8.9 ampules vs.53.0 +/- 15.9 ampules) and the duration of administration (15.3 +/- 3.6D vs. 9.8 +/- 2.6D) of these two groups. There are no significant differences about clinical pregnancy rate and live birth rate between group B and group C.
CONCLUSION: Prolonging administration gonadotropin on the unexpectedly poor ovarian responders does not lower live birth rate in vitro fertilization.
Zhaolian Wei; Xianxia Cheng; Huirong Li; Yunxia Cao; Lin Cong; Ping Zhou; Jun Li
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article     Date:  2010-03-17
Journal Detail:
Title:  Reproductive biology and endocrinology : RB&E     Volume:  8     ISSN:  1477-7827     ISO Abbreviation:  Reprod. Biol. Endocrinol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-25     Completed Date:  2010-05-06     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101153627     Medline TA:  Reprod Biol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  26     Citation Subset:  IM    
Reproductive Medicine Center, The First Affiliated Hospital, Anhui Medical University, Hefei, 230022, PR China.
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MeSH Terms
Dose-Response Relationship, Drug
Drug Administration Schedule
Fertility Agents, Female / administration & dosage
Fertilization in Vitro*
Follicle Stimulating Hormone, Human / administration & dosage
Gonadotropins / administration & dosage*
Infertility / diagnosis,  therapy*
Leuprolide / administration & dosage
Ovulation Induction / methods*
Pregnancy Rate
Retrospective Studies
Time Factors
Treatment Failure
Treatment Outcome
Reg. No./Substance:
0/Fertility Agents, Female; 0/Follicle Stimulating Hormone, Human; 0/Gonadotropins; 53714-56-0/Leuprolide

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