Document Detail

Effects of prolonged coronary hypotension on myocardial substrate utilization.
MedLine Citation:
PMID:  1208977     Owner:  NLM     Status:  MEDLINE    
Myocardial substrate utilization was investigated following experimental coronary hypotension in isolated in vitro perfused dog hearts. Control observations were made at the beginning and at the end of the experiments with afterload of 100 mm Hg. Between the two controls, the afterload was lowered to 50 mm Hg and kept at that level for 4 hours. The observations during the hypotensive period were compared to the two controls. Lactate uptake and the percentage contribution of the lactate to myocardial CO2 production were diminished during the hypotensive period. Myocardial free fatty acid (FFA) uptake and oxidation did not change significantly. Glucose uptake and myocardial respiratory quotient (RQ) were decreased. Thus, prolonged coronary hypotension caused a relative preference of FFA oxidation and diminished lactate and glucose uptake by the myocardium. It is of interest to note that these changes in substrate utilization were quite different from those observed during experimentally produced hemorrhagic hypotension or endotoxic shock.
J J Spitzer; L J Greenfield; L B Hinshaw
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Recent advances in studies on cardiac structure and metabolism     Volume:  10     ISSN:  0363-5872     ISO Abbreviation:  Recent Adv Stud Cardiac Struct Metab     Publication Date:  1975  
Date Detail:
Created Date:  1976-04-01     Completed Date:  1976-04-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0325677     Medline TA:  Recent Adv Stud Cardiac Struct Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  235-9     Citation Subset:  IM    
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MeSH Terms
Fatty Acids, Nonesterified / metabolism
Glucose / metabolism
Heart Failure / etiology
Hypotension / complications,  metabolism*
Lactates / metabolism
Myocardium / metabolism*
Shock / metabolism
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Lactates; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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