Document Detail

Effects of prolonged cold storage on the responsiveness of isolated and perfused canine intermediate auricular artery.
MedLine Citation:
PMID:  3861139     Owner:  NLM     Status:  MEDLINE    
Using the cannula inserting method, we investigated the effects of prolonged cold storage (5-7 days, at 4 degrees C) on vasoconstrictor responses of the isolated and perfused canine intermediate auricular artery to norepinephrine, tyramine, serotonin, histamine, prostaglandin F 2 alpha and potassium chloride. The vasoconstrictor responses to norepinephrine and potassium chloride were slightly enhanced by prolonged cold storage but not significantly, and those to serotonin and prostaglandin F 2 alpha were not influenced at all. On the other hand, the dose-response curve for tyramine shifted to the right in a parallel manner, and histamine-induced vasoconstriction was markedly potentiated by prolonged cold storage in a maximal increase in perfusion pressure. From these results, it is concluded that prolonged cold storage on the isolated canine intermediate auricular artery may not cause complete denervation of adrenergic nerve fibers and responsiveness to vasoactive substances except histamine remains almost the same in non-stored vessels.
T Ito; S Chiba
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  275     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-09-25     Completed Date:  1985-09-25     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  13-21     Citation Subset:  IM    
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MeSH Terms
Arteries / physiology
Cold Temperature
Ear / blood supply
Histamine / pharmacology
Muscle Contraction / drug effects
Muscle, Smooth, Vascular / drug effects,  physiology*
Norepinephrine / pharmacology
Potassium Chloride / pharmacology
Prostaglandins F / pharmacology
Serotonin / pharmacology
Tissue Preservation / methods*
Tyramine / pharmacology
Reg. No./Substance:
0/Prostaglandins F; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 51-45-6/Histamine; 51-67-2/Tyramine; 551-11-1/Dinoprost; 7447-40-7/Potassium Chloride

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