| Effects of prolonged administration of the angiotensin converting enzyme inhibitor CGS 16617 in normotensive volunteers. | |
| | |
MedLine Citation:
|
PMID: 2550244 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A new, orally active angiotensin converting enzyme (ACE) inhibitor, CGS 16617, has been evaluated in normotensive subjects during acute and prolonged administration. Single ascending doses of CGS 16617 20 to 100 mg were given to 9 normotensive volunteers at one week intervals and the changes in blood pressure, plasma ACE and renin activity were examined up to 72 h after drug intake. Also, CGS 16617 50 mg/day or placebo were given for 30 days to 8 and 6 normotensive subjects, respectively, maintained on an unrestricted salt diet. Blood pressure was measured daily in the office and ambulatory blood pressure profiles were also obtained before, during and after therapy, using the Remler M 2000 blood pressure recording system. CGS 16617 was an effective and long lasting ACE inhibitor. It did not induce a consistent change in blood pressure, but, the individual responses were very variable and several subjects experienced a clear decrease in the average of the blood pressures recorded during the daytime. |
| | |
Authors:
|
G Waeber; M Burnier; M Porchet; J Nussberger; B Waeber; H R Brunner |
Related Documents
:
|
6280474 - Angiotensin-converting enzyme inhibition, catecholamines and hemodynamics in essential ... 1835684 - Sch 34826: an overview of its profile as a neutral endopeptidase inhibitor and anf pote... 8748944 - Comparative studies on differential inhibition of the renin - angiotensin system in the... 6998684 - Comparison of the acute and chronic hemodynamic effects of captopril and guanethidine i... 2696754 - Current concepts in pathophysiology and diagnosis of compartment syndromes. 10389774 - A comparative study of hemodynamic and t-wave criteria for detecting intravascular inje... |
Publication Detail:
|
Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: European journal of clinical pharmacology Volume: 36 ISSN: 0031-6970 ISO Abbreviation: Eur. J. Clin. Pharmacol. Publication Date: 1989 |
Date Detail:
|
Created Date: 1989-10-19 Completed Date: 1989-10-19 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1256165 Medline TA: Eur J Clin Pharmacol Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 587-91 Citation Subset: IM |
Affiliation:
|
Division of Hypertension, University Hospital Lausanne, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Adult Angiotensin-Converting Enzyme Inhibitors / administration & dosage*, pharmacology Benzazepines / administration & dosage*, pharmacology Blood Pressure / drug effects* Humans Male Peptidyl-Dipeptidase A / blood Renin / blood Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin-Converting Enzyme Inhibitors; 0/Benzazepines; 109214-55-3/libenzapril; EC 3.4.15.1/Peptidyl-Dipeptidase A; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Acute calcium entry blockade inhibits the blood pressure but not the hormonal responses to angiotens...
Next Document: Effect of human atrial natriuretic peptide on blood glucose concentrations and hormone stimulation d...