Document Detail

Effects of progressive and maximal exercise on plasma levels of adhesion molecules in athletes with sickle cell trait with or without alpha-thalassemia.
MedLine Citation:
PMID:  16902065     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to examine the effects of exercise on soluble vascular cell adhesion molecule-1 (sVCAM-1) and intercellular adhesion molecule-1 (sICAM-1) in sickle cell trait (SCT) athletes with or without alpha-thalassemia. Six athletes with SCT, seven athletes with both SCT and alpha-thalassemia (SCTAT), and seven control athletes (Cont) performed an incremental and maximal test on cycloergometer. Levels of sICAM-1 and sVCAM-1 were assessed at rest, immediately after the end of exercise, and 1, 2, and 24 h after exercise. Although Cont and SCTAT groups exhibited similar basal plasma levels of inflammatory and adhesion molecules, the SCT group had higher sVCAM-1 basal concentrations. Incremental exercise resulted in a significant increase of sVCAM-1 in all subjects, which remained elevated only in the SCT group during the recovery period. In conclusion, as sVCAM-1 increased with exercise and during the recovery period, our findings support the concept that SCT athletes might be at risk for microcirculatory disturbances and adhesive phenomena developing at rest and several hours after exercise. alpha-Thalassemia might be considered protective among exercising SCT subjects.
Geraldine Monchanin; Laura D Serpero; Philippe Connes; Julien Tripette; Dieudonné Wouassi; Laurent Bezin; Alain Francina; Jeanne Ngongang; Monica de la Peña; Raphael Massarelli; David Gozal; Patrice Thiriet; Cyril Martin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-08-10
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  102     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-08     Completed Date:  2007-03-13     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  169-73     Citation Subset:  IM    
Equipe d'Accueil 647 Center of Research and Innovation on Sports, University of Lyon 1, Lyon, France.
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MeSH Terms
Exercise / physiology*
Exercise Test
Intercellular Adhesion Molecule-1 / blood,  metabolism*
Physical Exertion / physiology
Rest / physiology
Sickle Cell Trait / blood*,  physiopathology
Time Factors
Tumor Necrosis Factor-alpha / blood*
Vascular Cell Adhesion Molecule-1 / blood,  metabolism*
alpha-Thalassemia / blood*,  physiopathology
Reg. No./Substance:
0/Tumor Necrosis Factor-alpha; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1

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