Document Detail

Effects of progesterone treatment on expression of genes involved in uterine quiescence.
MedLine Citation:
PMID:  21795739     Owner:  NLM     Status:  MEDLINE    
An important action of progesterone during pregnancy is to maintain the uterus in a quiescent state and thereby prevent preterm labor. The causes of preterm labor are not well understood, so progesterone action on the myometrium can provide clues about the processes that keep the uterus from contracting prematurely. Accordingly, we have carried out Affymetrix GeneChip analysis of progesterone effects on gene expression in immortalized human myometrial cells cultured from a patient near the end of pregnancy. Progesterone appears to inhibit uterine excitability by a number of mechanisms, including increased expression of calcium and voltage-operated K(+) channels, which dampens the electrical activity of the myometrial cell, downregulation of agents, and receptors involved in myometrial contraction, reduction in cell signal components that lead to increased intracellular Ca(2+) concentrations in response to contractile stimuli, and downregulation of proteins involved in the cross-linking of actin and myosin filaments to produce uterine contractions.
Melvyn S Soloff; Yow-Jiun Jeng; Michael G Izban; Mala Sinha; Bruce A Luxon; Susan J Stamnes; Sarah K England
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  18     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-28     Completed Date:  2011-12-06     Revised Date:  2014-06-12    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  781-97     Citation Subset:  IM    
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MeSH Terms
Cell Line
Gene Expression Profiling / methods
Myometrium / cytology,  drug effects*,  physiology
Oligonucleotide Array Sequence Analysis
Progesterone / pharmacology*,  physiology
RNA / chemistry,  genetics
Reverse Transcriptase Polymerase Chain Reaction
Transcription, Genetic / drug effects*,  physiology
Uterine Contraction / drug effects*,  genetics,  physiology
Grant Support
Reg. No./Substance:
4G7DS2Q64Y/Progesterone; 63231-63-0/RNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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