| Effects of progesterone treatment on expression of genes involved in uterine quiescence. | |
| | |
MedLine Citation:
|
PMID: 21795739 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
An important action of progesterone during pregnancy is to maintain the uterus in a quiescent state and thereby prevent preterm labor. The causes of preterm labor are not well understood, so progesterone action on the myometrium can provide clues about the processes that keep the uterus from contracting prematurely. Accordingly, we have carried out Affymetrix GeneChip analysis of progesterone effects on gene expression in immortalized human myometrial cells cultured from a patient near the end of pregnancy. Progesterone appears to inhibit uterine excitability by a number of mechanisms, including increased expression of calcium and voltage-operated K(+) channels, which dampens the electrical activity of the myometrial cell, downregulation of agents, and receptors involved in myometrial contraction, reduction in cell signal components that lead to increased intracellular Ca(2+) concentrations in response to contractile stimuli, and downregulation of proteins involved in the cross-linking of actin and myosin filaments to produce uterine contractions. |
| | |
Authors:
|
Melvyn S Soloff; Yow-Jiun Jeng; Michael G Izban; Mala Sinha; Bruce A Luxon; Susan J Stamnes; Sarah K England |
Related Documents
:
|
12289529 - Order on the guidance file provided for in article l. 162-3 of the public health code, ... 18624139 - Discrepancies in the laws on identifying foetal sex and terminating a pregnancy in india. 20420269 - Misoprostol for second trimester abortion in women with prior uterine incisions. 17896259 - Pregnancy termination using vaginal misoprostol in women with more than one caesarean s... 18703439 - "having another child would be a life or death situation for her": understanding pregna... 8066099 - A comparison of the pregnancy-terminating potencies of three anti-progestins in guinea-... 11309749 - Evolution of two human skeletal markers of the squatting position: a diachronic study f... 7965499 - Amniotic fluid phospholipid analysis in the fetus with congenital diaphragmatic hernia. 9800669 - Fertility in anovulatory patients after primary cesarean section. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Reproductive sciences (Thousand Oaks, Calif.) Volume: 18 ISSN: 1933-7205 ISO Abbreviation: Reprod Sci Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-07-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101291249 Medline TA: Reprod Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 781-97 Citation Subset: IM |
Affiliation:
|
1Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Strong association between angiotensin I-converting enzyme I/D polymorphism and unexplained recurren...
Next Document: Effect of industrially produced trans fat on markers of systemic inflammation: evidence from a rando...