Document Detail

Effects of progesterone on blood pressure, plasma volume, and responses to hypotension.
MedLine Citation:
PMID:  9039032     Owner:  NLM     Status:  MEDLINE    
Gonadal steroids have been implicated in the control of blood pressure and fluid homeostasis. These experiments test the effect of progesterone in ovariectomized ewes on blood pressure, volume, and hormone responses to hypotension. Eight ewes were each studied in four conditions: ovariectomized, progesterone and estrogen replaced, progesterone replaced, or sham treated. During each treatment mean arterial pressure (MAP), plasma volume (PV), baroreflex responsiveness, and adrenocorticotropic hormone (ACTH), arginine vasopressin (AVP), and renin responses to hypotension were determined. Progesterone treatment significantly reduced resting MAP and increased PV compared with ovariectomy or sham treatments. Heart period at 85 mmHg was reduced with progesterone treatment. There was no effect of progesterone treatment on ACTH, AVP, or renin or heart rate responses to hypotension. Basal AVP levels were increased, and angiotensin II concentrations were decreased, by estrogen and progesterone and by sham treatments; plasma Na+ also tended to be increased during these treatments. These results suggest that a small increase in progesterone can reset resting MAP and PV without altering reflex heart rate or endocrine responses to hypotension.
M Pecins-Thompson; M Keller-Wood
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  272     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-03-31     Completed Date:  1997-03-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R377-85     Citation Subset:  IM    
Department of Pharmacodynamics, University of Florida, Gainesville 32610, USA.
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MeSH Terms
Adrenocorticotropic Hormone / blood
Arginine Vasopressin / blood
Baroreflex / drug effects
Blood Pressure / drug effects*
Blood Volume / drug effects*
Hypotension / blood,  physiopathology*
Osmolar Concentration
Progesterone / blood,  pharmacology*
Renin-Angiotensin System / drug effects
Sodium / blood
Grant Support
Reg. No./Substance:
113-79-1/Arginine Vasopressin; 57-83-0/Progesterone; 7440-23-5/Sodium; 9002-60-2/Adrenocorticotropic Hormone

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