| Effects of progesterone antagonist, lilopristone (ZK 98.734), on induction of menstruation, inhibition of nidation, and termination of pregnancy in bonnet monkeys. | |
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MedLine Citation:
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PMID: 2271724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of a progesterone antagonist, lilopristone (ZK 98.734), on induction of menstruation, inhibition of implantation or pregnancy, and termination of early and mid-pregnancy were studied in bonnet monkeys. In the regularly menstruating animals, administration of lilopristone (25 mg/day, s.c.) during the mid-luteal phase (Days 20-22 of the menstrual cycle) induced menstruation within 2-4 days after the initiation of treatment. A premature drop in circulating progesterone levels was also observed. The luteolytic effect of lilopristone was prevented by exogenous treatment with hCG; however, the animals showed premature menstruation, in spite of high progesterone levels (above 4 ng/ml). Treatment around the time of implantation (between Days 8 and 12 after the mid-cycle peak in estradiol levels) in mated animals provided 100% pregnancy protection. Treatment of pregnant animals on Days 30-32 of the menstrual cycle, i.e. about Day 20 after the estradiol peak, induced abortion in 8 of 10 animals. A significant (p less than 0.05) decrease in serum progesterone levels was observed on Day 3 after the initiation of treatment. However, the decrease was slower (slope: -0.36, r: 0.96) compared to that observed in nonpregnant animals (slope: -0.72, r: 0.95). In the other two animals, pregnancy was not affected. However, when the treatment was delayed until about Day 50 after the estradiol peak, all four animals aborted. This study suggests that lilopristone is a progesterone antagonist with a potential to induce menstruation, inhibit nidation, and terminate pregnancy. The antifertility effects are mediated through blocking progesterone action at the endometrium as well as decreasing progesterone bioavailability, which appears to be due to its effects on gonadotropin release. |
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Authors:
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C P Puri; R R Katkam; A D'Souza; W A Elger; R K Patil |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biology of reproduction Volume: 43 ISSN: 0006-3363 ISO Abbreviation: Biol. Reprod. Publication Date: 1990 Sep |
Date Detail:
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Created Date: 1991-02-25 Completed Date: 1991-02-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207224 Medline TA: Biol Reprod Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 437-43 Citation Subset: IM |
Affiliation:
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Institute for Research in Reproduction (ICMR), Parel, Bombay, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chorionic Gonadotropin / pharmacology Embryo Implantation / drug effects* Estradiol / metabolism Estrenes / pharmacology* Female Macaca radiata Menstruation / drug effects*, metabolism Pregnancy / drug effects* Progesterone / blood Progestins / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Estrenes; 0/Progestins; 50-28-2/Estradiol; 57-83-0/Progesterone; 97747-88-1/lilopristone |
| Comments/Corrections | |
Erratum In:
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Biol Reprod 1990 Oct;43(4):following 717 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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