Document Detail

Effects of products of activated leukocytes (lymphokines and monokines) on the growth of malignant trophoblast cells in vitro.
MedLine Citation:
PMID:  2447775     Owner:  NLM     Status:  MEDLINE    
Supernatants from activated leukocyte cultures and individual lymphokines and monokines were added to cultures of JEG-3 human gestational choriocarcinoma cells in vitro, and effects on cell proliferation were measured. Activated leukocyte culture supernatants, recombinant gamma-interferon, tumor necrosis factor, and colony-stimulating factor significantly inhibited JEG-3 proliferation. In contrast, high doses of both interleukin 1 and 2 stimulated JEG-3 proliferation. Low doses of B cell growth factor stimulated JEG-3 proliferation, whereas the highest dose was inhibitory. Further understanding of the effects of lymphokines and monokines on trophoblastic growth may provide important insights into immunologic mechanisms affecting early pregnancy development and tumor-host interactions in gestational trophoblastic neoplasia.
R S Berkowitz; J A Hill; C B Kurtz; D J Anderson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  158     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-02-24     Completed Date:  1988-02-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  199-203     Citation Subset:  AIM; IM    
Fearing Laboratory, Brigham and Women's Hospital, Boston, MA 02115.
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MeSH Terms
Biological Products / pharmacology*
Cell Division / drug effects
Cell Line
Choriocarcinoma / pathology*
Colony-Stimulating Factors / pharmacology
Concanavalin A / pharmacology
Interferons / pharmacology
Interleukins / pharmacology
Lymphocyte Culture Test, Mixed*
Lymphokines / pharmacology*
Tumor Necrosis Factor-alpha / pharmacology
Uterine Neoplasms / pathology*
Grant Support
Reg. No./Substance:
0/Biological Products; 0/Colony-Stimulating Factors; 0/Interleukins; 0/Lymphokines; 0/Monokines; 0/Tumor Necrosis Factor-alpha; 11028-71-0/Concanavalin A; 207137-56-2/Interleukin-4; 9008-11-1/Interferons

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