| Effects of products of activated leukocytes (lymphokines and monokines) on the growth of malignant trophoblast cells in vitro. | |
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MedLine Citation:
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PMID: 2447775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Supernatants from activated leukocyte cultures and individual lymphokines and monokines were added to cultures of JEG-3 human gestational choriocarcinoma cells in vitro, and effects on cell proliferation were measured. Activated leukocyte culture supernatants, recombinant gamma-interferon, tumor necrosis factor, and colony-stimulating factor significantly inhibited JEG-3 proliferation. In contrast, high doses of both interleukin 1 and 2 stimulated JEG-3 proliferation. Low doses of B cell growth factor stimulated JEG-3 proliferation, whereas the highest dose was inhibitory. Further understanding of the effects of lymphokines and monokines on trophoblastic growth may provide important insights into immunologic mechanisms affecting early pregnancy development and tumor-host interactions in gestational trophoblastic neoplasia. |
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Authors:
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R S Berkowitz; J A Hill; C B Kurtz; D J Anderson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 158 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1988 Jan |
Date Detail:
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Created Date: 1988-02-24 Completed Date: 1988-02-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 199-203 Citation Subset: AIM; IM |
Affiliation:
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Fearing Laboratory, Brigham and Women's Hospital, Boston, MA 02115. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Products
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pharmacology* Cell Division / drug effects Cell Line Choriocarcinoma / pathology* Colony-Stimulating Factors / pharmacology Concanavalin A / pharmacology Female Humans Interferons / pharmacology Interleukin-4 Interleukins / pharmacology Lymphocyte Culture Test, Mixed* Lymphokines / pharmacology* Monokines Tumor Necrosis Factor-alpha / pharmacology Uterine Neoplasms / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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CA 42738/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Products; 0/Colony-Stimulating Factors; 0/Interleukins; 0/Lymphokines; 0/Monokines; 0/Tumor Necrosis Factor-alpha; 11028-71-0/Concanavalin A; 207137-56-2/Interleukin-4; 9008-11-1/Interferons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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