Document Detail


Effects of primary resuscitation from shock on distribution of myocardial blood flow.
MedLine Citation:
PMID:  10658001     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hemorrhagic shock alters heterogeneity of regional myocardial perfusion (RMP) in the presence of critical coronary stenosis in pigs. Conventional resuscitation has failed to reverse these effects. We hypothesized that improvement of the resuscitation regime would lead to restoration of RMP heterogeneity. Diaspirin-cross-linked hemoglobin (10 g/dl; DCLHb) and human serum albumin (8.0 g/dl; HSA) were used. After baseline, a branch of the left coronary artery was stenosed; thereafter, hemorrhagic shock was induced. Resuscitation was performed with either DCLHb or HSA. At baseline, the fractcal dimension (D) of subendocardial myocardium was 1.31 +/- 0.083 (HSA) and 1.35 +/- 0.106 (DCLHb) (mean +/- SD). Coronary stenosis increased subendocardial D slightly but consistently only in the DCLHb group (1.39 +/- 0.104; P < 0.05). Shock reduced subendocardial D: 1.21 +/- 0.093 (HSA; P = 0.10), 1.25 +/- 0.092 (DCLHb; P < 0.05). Administration of DCLHb increased subendocardial D in 7 of 10 animals (1.31 +/- 0.097; P = 0.066). HSA was ineffective in this respect. DCLHb infusion restored arterial pressure and increased cardiac index (CI) to 80% of baseline values. Administration of HSA left animals hypotensive (69 mmHg) and increased CI to 122% of the average baseline value. Shock-induced disturbances of the distribution of RMP were improved by administration of DCLHb but not by HSA.
Authors:
M Kleen; O Habler; F Meisner; G Kemming; A Pape; K Messmer
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  88     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-03     Completed Date:  2000-03-03     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  373-85     Citation Subset:  IM    
Affiliation:
Institute for Surgical Research, University of Munich, 81366 Munich, Germany. kleen@icf.med.uni-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Aspirin / analogs & derivatives,  pharmacology
Coronary Circulation / drug effects,  physiology*
Coronary Vessels / drug effects,  physiopathology*
Hemodynamics / drug effects,  physiology
Hemoglobins / pharmacology
Humans
Hypotension / etiology
Middle Aged
Resuscitation*
Serum Albumin / adverse effects,  pharmacology
Shock, Hemorrhagic / physiopathology*,  therapy
Swine
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Serum Albumin; 0/diaspirin-cross-linked hemoglobin; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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