Document Detail

Effects of pressure on cerebrospinal fluid formation: nonsteady-state measurements in dogs.
MedLine Citation:
PMID:  7435599     Owner:  NLM     Status:  MEDLINE    
Effects of pressure on cerebrospinal fluid (CSF) formation were studied in dogs with a recirculatory spinal perfusion tracer clearance technique that does not require steady-state conditions. The data permit statistical analysis of the relationship between the rate of CSF formation and pressure for individual animals. Most animals showed no statistical relationship between CSF formation and intracranial pressure (ICP) and/or cerebral perfusion pressure (CPP). In this study, a disturbance of cerebral blood flow (CBF) autoregulation may have been present in five animals on the basis of CPP reductions, and four of this latter group showed formation to decrease with increasing ICP. It is suggested that CSF formation is normally pressure insensitive. With impaired autoregulation of CBF, formation may follow CBF and CPP passively.
F H Sklar; J Reisch; I Elashvili; T Smith; D M Long
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  239     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1980 Sep 
Date Detail:
Created Date:  1981-01-26     Completed Date:  1981-01-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R277-84     Citation Subset:  IM    
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MeSH Terms
Brain / blood supply
Cerebrospinal Fluid / physiology*
Hydrocephalus / physiopathology
Intracranial Pressure*
Regional Blood Flow
Statistics as Topic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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