| Effects of prescribed medications on cognition and behavior in frontotemporal lobar degeneration. | |
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MedLine Citation:
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PMID: 20930186 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A retrospective chart review of 21 patients meeting core clinical criteria for behavioral or aphasic variants of frontotemporal lobar degeneration (FTLD) was conducted. Data recorded included Folstein Mini-Mental State Examination (MMSE) scores, medications prescribed, and subjective reports of behavioral symptoms from each visit. Behaviors were graded on a scale from 1 to 3 and totaled for each visit. Changes in MMSE and behavior scores between visits 1 month and 6 months apart where a new medication was started were analyzed using a paired t test and were compared between medication classes using an unpaired t test. Acetylcholinesterase inhibitors (AChEIs) were associated with a decrease in MMSE scores by 1.6 (P = .02) and an increase in total behavior scores by 1.0 (P = .03). Mean MMSE and behavior scores were statistically more improved by selective serotonin reuptake inhibitors than AChEIs (P = .04). This data suggest a potential worsening of objective measures of cognitive and behavioral symptoms in FTLD with AChEI treatment. |
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Authors:
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David Irwin; Carol F Lippa; Andrea Rosso |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of Alzheimer's disease and other dementias Volume: 25 ISSN: 1938-2731 ISO Abbreviation: Am J Alzheimers Dis Other Demen Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-08 Completed Date: 2011-01-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101082834 Medline TA: Am J Alzheimers Dis Other Demen Country: United States |
Other Details:
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Languages: eng Pagination: 566-71 Citation Subset: IM |
Affiliation:
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Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Behavior / drug effects Cholinesterase Inhibitors / therapeutic use* Cognition / drug effects* Cognition Disorders / therapy Dopamine Agents / therapeutic use* Female Frontotemporal Lobar Degeneration / drug therapy* Humans Male Middle Aged Neuropsychological Tests Retrospective Studies Serotonin Uptake Inhibitors / therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Cholinesterase Inhibitors; 0/Dopamine Agents; 0/Serotonin Uptake Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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