| Effects of prenatal stress and exercise on dentate granule cells maturation and spatial memory in adolescent mice. | |
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MedLine Citation:
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PMID: 20638465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exposure to prenatal stress (PS) increases the risk of developing neurobehavioral disturbances later in life. Previous work has shown that exercise can exert beneficial effects on brain damage; however, it is unknown whether voluntary wheel running (VWR) can ameliorate the neurobehavioral impairments induced by PS in adolescent offspring. Pregnant CF-1 mice were randomly assigned to control (n=5) or stressed (n=5) groups. Pregnant dams were subjected to restraint stress between gestational days 14 and 21 (G14-21), whereas controls remained undisturbed in their home cages. On postnatal day 21 (P21), male pups were randomly assigned to the following experimental groups: control (n=5), stressed (n=5), and stressed mice+daily submitted to VWR (n=4). At P52, all groups were behaviorally evaluated in the Morris water maze. Animals were then sacrificed, and Golgi-impregnated granule cells were morphometrically analyzed. The results indicate that PS produced significant behavioral and neuronal impairments in adolescent offspring and that VWR significantly offset these deleterious effects. |
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Authors:
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Carlos Bustamante; Pamela Bilbao; William Contreras; Mauricio Martínez; Antonio Mendoza; Alvaro Reyes; Rodrigo Pascual |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-16 |
Journal Detail:
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Title: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience Volume: 28 ISSN: 1873-474X ISO Abbreviation: Int. J. Dev. Neurosci. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-14 Completed Date: 2011-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8401784 Medline TA: Int J Dev Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 605-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 ISDN. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Laboratorio de Neurociencias, Escuela de Kinesiología, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Chile. carlos.bustamante@ucv.cl |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dendrites / physiology, ultrastructure Female Hippocampus / cytology, physiology Male Memory / physiology* Mice Motor Activity / physiology* Neurons / cytology, physiology* Neuropsychological Tests Physical Conditioning, Animal* Pregnancy Prenatal Exposure Delayed Effects* Random Allocation Stress, Physiological* |
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