Document Detail

Effects of prenatal stress and exercise on dentate granule cells maturation and spatial memory in adolescent mice.
MedLine Citation:
PMID:  20638465     Owner:  NLM     Status:  MEDLINE    
Exposure to prenatal stress (PS) increases the risk of developing neurobehavioral disturbances later in life. Previous work has shown that exercise can exert beneficial effects on brain damage; however, it is unknown whether voluntary wheel running (VWR) can ameliorate the neurobehavioral impairments induced by PS in adolescent offspring. Pregnant CF-1 mice were randomly assigned to control (n=5) or stressed (n=5) groups. Pregnant dams were subjected to restraint stress between gestational days 14 and 21 (G14-21), whereas controls remained undisturbed in their home cages. On postnatal day 21 (P21), male pups were randomly assigned to the following experimental groups: control (n=5), stressed (n=5), and stressed mice+daily submitted to VWR (n=4). At P52, all groups were behaviorally evaluated in the Morris water maze. Animals were then sacrificed, and Golgi-impregnated granule cells were morphometrically analyzed. The results indicate that PS produced significant behavioral and neuronal impairments in adolescent offspring and that VWR significantly offset these deleterious effects.
Carlos Bustamante; Pamela Bilbao; William Contreras; Mauricio Martínez; Antonio Mendoza; Alvaro Reyes; Rodrigo Pascual
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-16
Journal Detail:
Title:  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience     Volume:  28     ISSN:  1873-474X     ISO Abbreviation:  Int. J. Dev. Neurosci.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-14     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8401784     Medline TA:  Int J Dev Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  605-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 ISDN. Published by Elsevier Ltd. All rights reserved.
Laboratorio de Neurociencias, Escuela de Kinesiología, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Chile.
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MeSH Terms
Dendrites / physiology,  ultrastructure
Hippocampus / cytology,  physiology
Memory / physiology*
Motor Activity / physiology*
Neurons / cytology,  physiology*
Neuropsychological Tests
Physical Conditioning, Animal*
Prenatal Exposure Delayed Effects*
Random Allocation
Stress, Physiological*

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