Document Detail

Effects of prenatal stress on anxiety and social interactions in adult rats.
MedLine Citation:
PMID:  16290208     Owner:  NLM     Status:  MEDLINE    
Deficits in social behavior are found in several neuro-psychiatric disorders with a presumed developmental origin. The aim of the present study is to determine if prenatal stress at a given day of gestation alters social behavior in adult offspring. Pregnant rats were exposed to an acute stress (presence of a cat) either at the 10th (S10), the 14th (S14) or the 19th (S19) gestational day. When adult, their offsprings were studied in anxiety, neophobic and social behaviors. The results showed that S10 and S19 rats were more anxious and less aggressive than control rats, while the anxious and aggressive behavior of S14 rats was similar to that of the control ones. It is suggested that day 14 of pregnancy is a hyposensitive period to stressful agents due to an important plasticity of the developing gross nervous structures.
V Patin; B Lordi; A Vincent; J Caston
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-11-14
Journal Detail:
Title:  Brain research. Developmental brain research     Volume:  160     ISSN:  0165-3806     ISO Abbreviation:  Brain Res. Dev. Brain Res.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-02     Completed Date:  2006-02-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8908639     Medline TA:  Brain Res Dev Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  265-74     Citation Subset:  IM    
Laboratoire de Neurobiologie de l'Apprentissage, UPRES PSY.CO 1780, Universit? de Rouen, Facult? des Sciences 76821 Mont-Saint-Aignan Cedex, France.
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MeSH Terms
Age Factors
Aggression / physiology
Analysis of Variance
Anxiety / psychology*
Behavior, Animal
Discrimination (Psychology) / physiology
Interpersonal Relations*
Maze Learning / physiology
Prenatal Exposure Delayed Effects*
Reaction Time
Stress, Psychological / psychology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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