Document Detail

Effects of prenatal multimicronutrient supplementation on pregnancy outcomes: a meta-analysis.
MedLine Citation:
PMID:  19506270     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Reduced intake of micronutrients during pregnancy exposes women to nutritional deficiencies and may affect fetal growth. We conducted a systematic review to examine the efficacy of prenatal supplementation with multimicronutrients on pregnancy outcomes.
METHODS: We searched MEDLINE, EMBASE, CINAHL and the Cochrane Library for relevant articles published in English up to December 2008. We also searched the bibliographies of selected articles as well as clinical trial registries. The primary outcome was low birth weight; secondary outcomes were preterm birth, small-for-gestational-age infants, birth weight and gestational age.
RESULTS: We observed a significant reduction in the risk of low birth weight among infants born to women who received multimicronutrients during pregnancy compared with placebo (relative risk [RR] 0.81, 95% confidence interval [CI] 0.73-0.91) or iron-folic acid supplementation (RR 0.83, 95% CI 0.74-0.93). Birth weight was significantly higher among infants whose mothers were in the multimicronutrient group than among those whose mothers received iron-folic acid supplementation (weighted mean difference 54 g, 95% CI 36 g-72 g). There was no significant differences in the risk of preterm birth or small-for-gestational-age infants between the 3 study groups.
INTERPRETATION: Prenatal multimicronutrient supplementation was associated with a significantly reduced risk of low birth weight and with improved birth weight when compared with iron-folic acid supplementation. There was no significant effect of multimicronutrient supplementation on the risk of preterm birth or small-for-gestational-age infants.
Prakesh S Shah; Arne Ohlsson;
Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne     Volume:  180     ISSN:  1488-2329     ISO Abbreviation:  CMAJ     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-09     Completed Date:  2009-06-25     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  9711805     Medline TA:  CMAJ     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  E99-108     Citation Subset:  AIM; IM    
Department of Paediatrics, Mount Sinai Hospital, University of Toronto, Ont.
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MeSH Terms
Birth Weight / drug effects,  physiology*
Dietary Supplements*
Fetal Development / physiology*
Folic Acid / administration & dosage
Infant, Low Birth Weight / physiology
Infant, Newborn
Infant, Small for Gestational Age
Iron / administration & dosage
Micronutrients / administration & dosage*
Nutrition Assessment
Pregnancy Outcome*
Premature Birth / epidemiology
Reg. No./Substance:
0/Micronutrients; 59-30-3/Folic Acid; 7439-89-6/Iron
Prakesh S Shah / ; Arne Ohlsson / ; Vibhuti Shah / ; Kellie E Murphy / ; Sarah D McDonald / ; Eileen Hutton / ; Christine Newburn-Cook / ; Corine Frick / ; Fran Scott / ; Victoria Allen / ; Joseph Beyene /
Comment In:
CMAJ. 2009 Jun 9;180(12):1188-9   [PMID:  19506273 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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