Document Detail

Effects of prenatal morphine on hypothalamic metabolism of neurotransmitters and gonadal and adrenal activities, during the early postnatal period in the rat.
MedLine Citation:
PMID:  8829146     Owner:  NLM     Status:  MEDLINE    
It is noteworthy that exposure to opiates during fetal development results in permanent changes in adults related to morphological, behavioral and biochemical measures; however little is known concerning the effects of such drugs in early postnatal life. We investigated in newborn rats the effects of prenatal morphine-exposure on both-the hypothalamic metabolism of norepinephrine (NE), serotonin (5 HT) and neuropeptide Y (NPY)-the activity of the hypothalamo-pituitary gonadal and adrenal axes. In a previous study performed in newborns of untreated mothers, we reported some sex-dependent changes in the metabolism of NE, 5 HT and NPY in the hypothalamus and an early activation of the gonadostimulating function and of the corticostimulating one. In control newborns from saline-treated mothers, a slight increase in the hypothalamic metabolism of NE (males) and 5 HT (males and females) was observed and it was comparable in both sexes. On the other hand, the hypothalamic content of NPY was unaffected in early postnatal period in newborn males as well as in females. These changes observed on hypothalamic metabolisms are temporally correlated with the early postnatal activation of the corticostimulating function in neonates of both sexes and that of the gonadostimulating one, mainly in males. Prenatal morphine exposure altered the hypothalamic metabolism of 5 HT which was increased mainly in newborn females but did not affect either the metabolism of NE or the NPY content of the hypothalamus. The more drastic effect of the prenatal morphine treatment is the atrophy and hypoactivity of the adrenals in newborns of both sexes at birth time and during the early postnatal period. In contrast morphine did not impair postnatal surge of the plasma testosterone level in male pups as well as late and slight increase of plasma estradiol in female ones.
J Lesage; F Bernet; V Montel; J P Dupouy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurochemical research     Volume:  21     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-12-20     Completed Date:  1996-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  723-32     Citation Subset:  IM    
Centre de Biologie Cellulaire, Neuroendocrinologie Expérimentale Neuroendocrinologie du Développement, Université de Lille, Villeneuve d'Ascq, France.
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MeSH Terms
Adrenal Glands / drug effects*,  growth & development,  metabolism
Animals, Newborn
Corticosterone / blood
Hypothalamus / drug effects*,  growth & development,  metabolism
Morphine / pharmacology*
Neuropeptide Y / metabolism
Neurotransmitter Agents / metabolism*
Norepinephrine / metabolism
Pituitary Gland / drug effects,  growth & development,  metabolism
Prenatal Exposure Delayed Effects*
Rats, Wistar
Serotonin / metabolism
Testis / drug effects*,  growth & development,  metabolism
Testosterone / metabolism
Reg. No./Substance:
0/Neuropeptide Y; 0/Neurotransmitter Agents; 50-22-6/Corticosterone; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 57-27-2/Morphine; 58-22-0/Testosterone

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