| Effects of prenatal morphine on hypothalamic metabolism of neurotransmitters and gonadal and adrenal activities, during the early postnatal period in the rat. | |
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MedLine Citation:
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PMID: 8829146 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is noteworthy that exposure to opiates during fetal development results in permanent changes in adults related to morphological, behavioral and biochemical measures; however little is known concerning the effects of such drugs in early postnatal life. We investigated in newborn rats the effects of prenatal morphine-exposure on both-the hypothalamic metabolism of norepinephrine (NE), serotonin (5 HT) and neuropeptide Y (NPY)-the activity of the hypothalamo-pituitary gonadal and adrenal axes. In a previous study performed in newborns of untreated mothers, we reported some sex-dependent changes in the metabolism of NE, 5 HT and NPY in the hypothalamus and an early activation of the gonadostimulating function and of the corticostimulating one. In control newborns from saline-treated mothers, a slight increase in the hypothalamic metabolism of NE (males) and 5 HT (males and females) was observed and it was comparable in both sexes. On the other hand, the hypothalamic content of NPY was unaffected in early postnatal period in newborn males as well as in females. These changes observed on hypothalamic metabolisms are temporally correlated with the early postnatal activation of the corticostimulating function in neonates of both sexes and that of the gonadostimulating one, mainly in males. Prenatal morphine exposure altered the hypothalamic metabolism of 5 HT which was increased mainly in newborn females but did not affect either the metabolism of NE or the NPY content of the hypothalamus. The more drastic effect of the prenatal morphine treatment is the atrophy and hypoactivity of the adrenals in newborns of both sexes at birth time and during the early postnatal period. In contrast morphine did not impair postnatal surge of the plasma testosterone level in male pups as well as late and slight increase of plasma estradiol in female ones. |
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Authors:
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J Lesage; F Bernet; V Montel; J P Dupouy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurochemical research Volume: 21 ISSN: 0364-3190 ISO Abbreviation: Neurochem. Res. Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1996-12-20 Completed Date: 1996-12-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 723-32 Citation Subset: IM |
Affiliation:
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Centre de Biologie Cellulaire, Neuroendocrinologie Expérimentale Neuroendocrinologie du Développement, Université de Lille, Villeneuve d'Ascq, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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drug effects*,
growth & development,
metabolism Animals Animals, Newborn Corticosterone / blood Female Hypothalamus / drug effects*, growth & development, metabolism Male Morphine / pharmacology* Neuropeptide Y / metabolism Neurotransmitter Agents / metabolism* Norepinephrine / metabolism Pituitary Gland / drug effects, growth & development, metabolism Pregnancy Prenatal Exposure Delayed Effects* Rats Rats, Wistar Serotonin / metabolism Testis / drug effects*, growth & development, metabolism Testosterone / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptide Y; 0/Neurotransmitter Agents; 50-22-6/Corticosterone; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 57-27-2/Morphine; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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