Document Detail

Effects of prenatal exposure to mercury on cognitive and psychomotor function in one-year-old infants: epidemiologic cohort study in Poland.
MedLine Citation:
PMID:  16275013     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of the study is to assess the cognitive and psychomotor status of 1-year-old infants whose mothers were exposed to low, but varying, amounts of mercury during pregnancy.
METHODS: Mercury levels in cord and maternal blood at delivery were used to assess prenatal environmental exposure to mercury. Bayley Scales of Infant Development were used to assess neurobehavioral health outcomes. The cohort consisted of 233 infants who were born at 33 to 42 weeks of gestation between January 2001 and March 2003 to mothers attending ambulatory prenatal clinics in the first and second trimesters of pregnancy. Enrollment included only nonsmoking women with singleton pregnancies between the ages of 18 and 35 years who were free from chronic diseases.
RESULTS: The geometric mean (GM) for maternal blood mercury level for the group of infants with normal neurocognitive performance was lower (GM = 0.52 mug/L; 95% confidence interval [CI], 0.46-0.58) than that observed in the group with delayed performance (GM = 0.75 mug/L; 95% CI, 0.59-0.94), and this difference was significant (p = 0.010). The GM of cord blood mercury level in the normal group also was lower (GM = 0.85 mug/L; 95% CI, 0.78-0.93) than that observed in the group with delayed performance (GM = 1.05 mug/L; 95% CI, 0.87-1.27), and this difference was of borderline significance (p = 0.070). The relative risk (RR) for delayed performance increased more than threefold (RR = 3.58; 95% CI, 1.40-9.14) if cord blood mercury level was greater than 0.80 mug/L. Risk for delayed performance in the group of infants with greater maternal mercury levels (>0.50 mug/L) also was significantly greater (RR = 2.82; 95% CI, 1.17-6.79) compared with children whose mothers had mercury levels less than 0.50 mug/L.
CONCLUSIONS: The results may be of public health importance because delayed psychomotor or mental performance in infants is assumed to be an indicator of later neurocognitive development in children, which may persist into adult life.
Wieslaw Jedrychowski; Jeffery Jankowski; Elzbieta Flak; Anita Skarupa; Elzbieta Mroz; Elzbieta Sochacka-Tatara; Iwona Lisowska-Miszczyk; Agnieszka Szpanowska-Wohn; Virginia Rauh; Zbigniew Skolicki; Irena Kaim; Frederica Perera
Related Documents :
17338843 - Effect of the sars outbreak on visits to a community hospital emergency department.
25220123 - Use of erythropoietin is associated with threshold retinopathy of prematurity (rop) in ...
11744643 - Tidal exhaled nitric oxide in healthy, unsedated newborn infants with prenatal tobacco ...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2005-11-07
Journal Detail:
Title:  Annals of epidemiology     Volume:  16     ISSN:  1047-2797     ISO Abbreviation:  Ann Epidemiol     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-23     Completed Date:  2006-12-05     Revised Date:  2013-05-24    
Medline Journal Info:
Nlm Unique ID:  9100013     Medline TA:  Ann Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  439-47     Citation Subset:  IM    
Chair of Epidemiology and Preventive Medicine, College of Medicine, Jagiellonian University, Krakow, Poland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cognition / drug effects*
Cohort Studies
Environmental Exposure
Fetal Blood / metabolism
Fish Products / adverse effects
Infant, Newborn
Mercury / blood
Mercury Poisoning / blood,  epidemiology,  psychology*
Poland / epidemiology
Prenatal Exposure Delayed Effects*
Psychomotor Performance / drug effects*
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Estimating the incidence of dementia: the impact of adjusting for subject attrition using health car...
Next Document:  Motor cortex excitability during unilateral muscle activity.