| Effects of prenatal ethanol and long-chain n-3 fatty acid supplementation on development in mice. 1. Body and brain growth, sensorimotor development, and water T-maze reversal learning. | |
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MedLine Citation:
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PMID: 2378425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pregnant mice were fed equivalent daily amounts of a liquid diet containing 25% (kcal) ethanol, or with maltose dextrin substituted isocalorically for ethanol. In addition, the diet contained 20% oil; this was either of two mixtures, one comprised of predominantly n-6 (18:2n-6) fatty acids, and the other containing an equivalent amount of n-6, but supplemented with a source of long chain n-3 (20:5n-3, 22:6n-3) fatty acids. An additional control group was fed lab chow ad libitum. The treatment was implemented from day 7 to 17 of gestation, whereafter all groups were fed lab chow. Ethanol decreased maternal weight gain and pup body and brain weight; it also retarded both sensory and motor development in the pups and impeded reversal learning in a water maze. The n-3 supplementation lowered maternal blood alcohol concentration, but counteracted only some of the effects of ethanol, by increasing maternal weight gain and pup body weight, and also by enhancing sensory development in the pups. Such effects were additive, in that they were also present in the maltose-dextrin control group. These findings suggest that n-3 supplementation may ameliorate some of the effects of ethanol on neurobehavioral development, but the magnitude of the effect appears to be small. |
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Authors:
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P E Wainwright; G R Ward; D Winfield; Y S Huang; D E Mills; R P Ward; D McCutcheon |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Alcoholism, clinical and experimental research Volume: 14 ISSN: 0145-6008 ISO Abbreviation: Alcohol. Clin. Exp. Res. Publication Date: 1990 Jun |
Date Detail:
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Created Date: 1990-09-04 Completed Date: 1990-09-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7707242 Medline TA: Alcohol Clin Exp Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 405-12 Citation Subset: IM |
Affiliation:
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Department of Health Studies, University of Waterloo, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / drug effects* Brain / drug effects* Discrimination Learning / drug effects* Ethanol / pharmacokinetics Fatty Acids, Omega-3 / administration & dosage* Female Fetal Alcohol Syndrome / psychology* Mice Orientation / drug effects* Pregnancy Psychomotor Performance / drug effects* Reversal Learning / drug effects* Social Environment |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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