Document Detail


Effects of prenatal ethanol exposure on the development of Bergmann glia and astrocytes in the rat cerebellum: an immunohistochemical study.
MedLine Citation:
PMID:  1613136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The consequences of prenatal ethanol exposure on the postnatal development of Bergmann glia and astrocytes in the rat cerebellum were investigated by using glial fibrillary acidic protein (GFAP) immunolabeling. Pregnant rats were either fed with an ethanol containing liquid diet (6.7% v/v) or pair-fed with an isocaloric diet throughout gestation. On postnatal day (PD) 15 and 22, parasagittal sections of the cerebellar vermis from female offspring were processed for GFAP immunohistochemistry to assess the development of Bergmann glia and astrocytes in lobules I, VII, and X and astrocytes in the central core of white matter. On PD 15, compared to control animals, ethanol exposed animals had fewer GFAP positive Bergmann glial fibers per unit length of molecular layer; a significantly greater percentage of morphologically immature Bergmann fibers; a significantly greater GFAP positive astrocytic area per unit area of internal granular layer and central white matter; and the astrocytic processes were wider and more closely packed. These glial changes were associated with significantly thicker external granular layer in all 3 lobules. However, no significant differences were seen between the ethanol exposed and control animals on PD 22, indicating "catch-up growth" in the ethanol exposed animals during the third postnatal week. These results suggest that prenatal ethanol exposure causes (1) delayed maturation of Bergmann glia, which in turn contributes to the delayed migration of granule cells; and (2) alterations in the normal postnatal development of astrocytes.
Authors:
A K Shetty; D E Phillips
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  321     ISSN:  0021-9967     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-07-30     Completed Date:  1992-07-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  19-32     Citation Subset:  IM    
Affiliation:
Department of Biology, Montana State University, Bozeman 59717-0346.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Astrocytes / cytology,  drug effects,  physiology*
Cerebellum / cytology,  drug effects,  embryology*
Ethanol / pharmacology*
Female
Glial Fibrillary Acidic Protein / analysis*
Immunohistochemistry / methods
Maternal-Fetal Exchange
Nerve Fibers / drug effects,  physiology,  ultrastructure
Neuroglia / cytology,  drug effects,  physiology*
Pregnancy
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
AA7042/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Glial Fibrillary Acidic Protein; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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