Document Detail

Effects of prenatal betamethasone administration on leptin and adiponectin concentrations in maternal and fetal circulation.
MedLine Citation:
PMID:  18456235     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to determine the effects of in vivo administration of prenatal betamethasone on leptin and adiponectin concentration in maternal and fetal circulation.
STUDY DESIGN: Blood samples were collected from 35 pregnant women receiving betamethasone for threatened preterm delivery before and at different time points after drug administration. Cord blood was collected at delivery in infants born from mothers treated with betamethasone and in 15 infants who delivered at the same gestational age not receiving betamethasone.
RESULTS: Betamethasone caused an approximately 170% increase in maternal leptin at 24 hours after betamethasone, whereas it had no effects on adiponectin concentration. Betamethasone affects neonatal leptin and adiponectin levels in a time-dependent manner. The glucocorticoid-induced changes in the relationship between these adipokines in maternal and fetal circulation was long lasting.
CONCLUSION: These results provide the first evidence for in vivo effects of glucocorticoids on maternal and fetal adipokines relationship in human pregnancy.
Emanuela Marinoni; Claudio Letizia; Francesca Ciardo; Giovanna Corona; Massimo Moscarini; Romolo Di Iorio
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Publication Detail:
Type:  Journal Article     Date:  2008-05-23
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  199     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-04     Completed Date:  2008-08-29     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  141.e1-6     Citation Subset:  AIM; IM    
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MeSH Terms
Adiponectin / blood*
Adipose Tissue / physiology
Betamethasone / administration & dosage*
Enzyme-Linked Immunosorbent Assay
Fetal Blood / chemistry*
Fetus / physiology*
Glucocorticoids / administration & dosage*
Leptin / blood*
Placenta / physiology
Pregnancy / physiology*
Time Factors
Grant Support
G0600422//Medical Research Council
Reg. No./Substance:
0/Adiponectin; 0/Glucocorticoids; 0/Leptin; 9842X06Q6M/Betamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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