Document Detail

Effects of prenatal 5-methoxytryptamine and parachlorophenylalanine on serotonergic uptake and behavior in the neonatal rat.
MedLine Citation:
PMID:  2976167     Owner:  NLM     Status:  MEDLINE    
Parachlorophenylalanine (pCPA) or 5-methoxytryptamine (5MT) was administered to pregnant Sprague Dawley rats from day 8 (D8) of gestation till D17 and from D12 until birth respectively. Birth weights of both drug groups of neonates were approximately 20% less than the saline-injected controls. 5MT neonates showed a significant reduction of high affinity 3H-5HT uptake in the brainstem at all three time points: D1, D15, D30, and a slight reduction in the forebrain reaching significance only on D30. The pCPA animals showed a significant reduction in the brainstem and forebrain on D1 and D30, but only a small nonsignificant reduction in both areas on D15. Behaviors measured on day 15 revealed that in general activity, spontaneous alternation, and passive avoidance both drug groups of neonates showed deficits: less activity, less alternation, and less avoidance.
A Shemer; P M Whitaker-Azmitia; E C Azmitia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  30     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1989-04-04     Completed Date:  1989-04-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  847-51     Citation Subset:  IM    
Department of Biology, New York University, NY 10003.
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MeSH Terms
5-Methoxytryptamine / pharmacology*
Animals, Newborn
Avoidance Learning / drug effects*
Brain / drug effects,  metabolism*
Brain Stem / drug effects,  metabolism
Fenclonine / pharmacology*
Maternal-Fetal Exchange
Motor Activity / drug effects
Rats, Inbred Strains
Reference Values
Serotonin / metabolism*,  pharmacology*
Synaptosomes / metabolism
Reg. No./Substance:
50-67-9/Serotonin; 608-07-1/5-Methoxytryptamine; 7424-00-2/Fenclonine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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