| Effects of premature weaning and diet on lung growth and appearance of adenylate cyclase activator in rat lung. | |
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MedLine Citation:
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PMID: 2011119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Early weaning of rat pups on day 16 to semi-ground Purina chow food and drinking water, ad libitum, delayed growth of body and lungs, and the appearance of adenylate cyclase activator (ACA) in lung after day 22. However, early weaning of pups to either milk or a gel diet containing semi-ground Purina chow food, agarose gel, water (30:1:69, w/w), and drinking water, restored lung and body growth and the appearance of ACA to control values. Early weaning of pups to dry semi-ground Purina chow food and drinking water also induced a transient rise in ACA on day 19. This early rise in ACA was completely absent in pups weaned on day 16 to milk, whereas it persisted in pups weaned similarly to a gel diet. Interestingly, lung glycogen decreased on day 19 in pups weaned early to dry semi-ground Purina chow food without (group 2) or with triiodothyronine administration (group 3), and on day 25 after normal weaning on day 22 (Nijjar, M.S. Biochim. Biophys. Acta 586: 464-472, 1979). These data indicate 1) that reduced food intake (starvation) in pups weaned on day 16 to dry semi-ground Purina chow food was responsible for the delayed growth of body and lung, and the delayed appearance of ACA in lung after day 22, and 2) that a change in diet from milk to Purina chow food and associated alterations in hormones, possibly cortisol and insulin, were responsible for the appearance of ACA in rat lung.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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M S Nijjar; G M Hatch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular and cellular biochemistry Volume: 101 ISSN: 0300-8177 ISO Abbreviation: Mol. Cell. Biochem. Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-05-07 Completed Date: 1991-05-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 59-66 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenylate Cyclase
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metabolism* Animals Diet* Enzyme Activation Glycogen / metabolism Lung / enzymology, growth & development*, metabolism Membrane Proteins / metabolism Phosphorylases / metabolism Rats Rats, Inbred Strains Weaning* |
| Chemical | |
Reg. No./Substance:
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0/Membrane Proteins; 9005-79-2/Glycogen; EC 2.4.1.-/Phosphorylases; EC 4.6.1.1/Adenylate Cyclase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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