Document Detail

Effects of premature weaning and diet on lung growth and appearance of adenylate cyclase activator in rat lung.
MedLine Citation:
PMID:  2011119     Owner:  NLM     Status:  MEDLINE    
Early weaning of rat pups on day 16 to semi-ground Purina chow food and drinking water, ad libitum, delayed growth of body and lungs, and the appearance of adenylate cyclase activator (ACA) in lung after day 22. However, early weaning of pups to either milk or a gel diet containing semi-ground Purina chow food, agarose gel, water (30:1:69, w/w), and drinking water, restored lung and body growth and the appearance of ACA to control values. Early weaning of pups to dry semi-ground Purina chow food and drinking water also induced a transient rise in ACA on day 19. This early rise in ACA was completely absent in pups weaned on day 16 to milk, whereas it persisted in pups weaned similarly to a gel diet. Interestingly, lung glycogen decreased on day 19 in pups weaned early to dry semi-ground Purina chow food without (group 2) or with triiodothyronine administration (group 3), and on day 25 after normal weaning on day 22 (Nijjar, M.S. Biochim. Biophys. Acta 586: 464-472, 1979). These data indicate 1) that reduced food intake (starvation) in pups weaned on day 16 to dry semi-ground Purina chow food was responsible for the delayed growth of body and lung, and the delayed appearance of ACA in lung after day 22, and 2) that a change in diet from milk to Purina chow food and associated alterations in hormones, possibly cortisol and insulin, were responsible for the appearance of ACA in rat lung.(ABSTRACT TRUNCATED AT 250 WORDS)
M S Nijjar; G M Hatch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  101     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-05-07     Completed Date:  1991-05-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  59-66     Citation Subset:  IM    
Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada.
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MeSH Terms
Adenylate Cyclase / metabolism*
Enzyme Activation
Glycogen / metabolism
Lung / enzymology,  growth & development*,  metabolism
Membrane Proteins / metabolism
Phosphorylases / metabolism
Rats, Inbred Strains
Reg. No./Substance:
0/Membrane Proteins; 9005-79-2/Glycogen; EC 2.4.1.-/Phosphorylases; EC Cyclase

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