| Effects of pregnancy and nutritional status on alcohol metabolism. | |
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MedLine Citation:
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PMID: 17718402 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Metabolism of alcohol (i.e., ethanol) is regulated by genetic and environmental factors as well as physiologic state. For a given alcohol intake, the rate of alcohol clearance, which ultimately determines tissue ethanol concentrations, may be the most significant risk factor for many of the detrimental effects of alcohol. Faster ethanol clearance would help minimize target tissue concentrations, and in pregnant women, mitigate fetal alcohol exposure. Much remains to be known about the effects of the altered endocrine milieu of pregnancy on alcohol metabolism and clearance in the mother. Research has shown that among pregnant rats allowed unrestricted access to alcohol and those fed alcohol containing liquid diets under experimental conditions via a feeding tube (total enteral nutrition [TEN]), urine ethanol concentrations (and thus blood and tissue ethanol concentrations) are lower in pregnant rats compared with non-pregnant females given the same dose of ethanol. Maternal nutritional status also is an important determinant of fetal alcohol toxicity. Research using the TEN system has demonstrated that alcohol-induced fetal growth retardation is potentiated by undernutrition in part via impaired alcohol metabolism and clearance. |
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Authors:
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Kartik Shankar; Martin J J Ronis; Thomas M Badger |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism Volume: 30 ISSN: 1535-7414 ISO Abbreviation: Alcohol Res Health Publication Date: 2007 |
Date Detail:
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Created Date: 2007-08-27 Completed Date: 2007-10-23 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 100900708 Medline TA: Alcohol Res Health Country: United States |
Other Details:
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Languages: eng Pagination: 55-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Dehydrogenase
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metabolism Aldehyde Dehydrogenase / metabolism Animals Disease Models, Animal Ethanol / metabolism*, pharmacokinetics, toxicity Female Fetal Alcohol Syndrome / enzymology* Fetus / drug effects Humans Malnutrition / enzymology, metabolism* Metabolic Clearance Rate Pregnancy / metabolism* Rats |
| Grant Support | |
ID/Acronym/Agency:
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R01AA12819/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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64-17-5/Ethanol; EC 1.1.1.1/Alcohol Dehydrogenase; EC 1.2.1.3/Aldehyde Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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