Document Detail


Effects of pregnancy after treatment for breast carcinoma on survival and risk of recurrence.
MedLine Citation:
PMID:  14745861     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The goal of the current study was to assess the effect of pregnancy on the subsequent risk of recurrence after treatment for breast carcinoma, adjusting for established prognostic factors. METHODS: Between 1974 and 1998, 383 patients age < or =35 years were treated for breast carcinoma with adjuvant chemotherapy at The University of Texas M. D. Anderson Cancer Center (Houston, TX). The median follow-up period was 13 years. Of these, 13 patients were excluded from analysis, as no history was available regarding pregnancy; 240 (65%) were >30 years old; 47 (13%) had at least 1 pregnancy after therapy; 32 had full-term pregnancies; 10 had spontaneous or elective abortions; 4 had miscarriages; and 1 had a premature delivery. Estrogen receptor (ER) status, lymph node involvement, and disease stage were evaluated as potential risk factors for recurrence. Information on ER status was unavailable for 123 (33%) patients. RESULTS: Patients who experienced a pregnancy tended to have earlier-stage disease (Stage I/II: 80% vs. 73%), fewer positive lymph nodes (<4: 87% vs. 52%), more ER negativity (68% vs. 58%), and younger age (<30 years: 57% vs. 32%) than patients who did not. The incidence of disease recurrence was 23% for women who experienced a pregnancy and 54% for women who did not. The hazard ratio (using the multivariate Cox proportional hazards model) for disease recurrence in patients with posttreatment pregnancy was 0.71 (P=0.4). CONCLUSIONS: In the current study population, pregnancy was not associated with an increased risk of disease recurrence or poorer survival in patients previously treated for breast carcinoma.
Authors:
L Johnetta Blakely; Aman U Buzdar; Jose A Lozada; Samer A Shullaih; Emma Hoy; Terry L Smith; Gabriel N Hortobagyi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer     Volume:  100     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-27     Completed Date:  2004-02-19     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  465-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2003 American Cancer Society.
Affiliation:
Division of Cancer Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antineoplastic Combined Chemotherapy Protocols / adverse effects,  therapeutic use
Breast Neoplasms / mortality*,  pathology,  therapy*
Carcinoma / pathology,  therapy*
Combined Modality Therapy
Confidence Intervals
Female
Humans
Incidence
Mastectomy, Segmental / methods
Neoplasm Recurrence, Local / epidemiology*,  pathology
Pregnancy
Pregnancy Complications, Neoplastic / epidemiology*,  pathology
Pregnancy Outcome
Pregnancy, High-Risk*
Probability
Prognosis
Proportional Hazards Models
Reference Values
Retrospective Studies
Risk Factors
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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