Document Detail


Effects of prednisone on mucociliary clearance in a murine model.
MedLine Citation:
PMID:  23026626     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
All transplant patients are at increased risk of developing pulmonary infections, a significant cause of morbidity and mortality. Immunosuppressants increase the incidence of lung infection by acting not only directly on the inflammatory cells, but also on the native immune system. Experimental studies have shown corticosteroid therapy, which is used in most immunosuppressive protocols after transplantation, to suppress mucus production by inhibiting calceiform. The objective of this study was to evaluate the effects of prednisone on mucociliary clearance. A total of 120 male Wistar rats were distributed into 4 groups. Animals in P1, P2, and P3 groups received daily doses of prednisone (0.625, 1.25, and 2.5 mg/kg/d), and hosts in the Sal group underwent gavage with saline solution (2.5 mL/d). After 7, 15, and 30 days, treatment, animals were killed. We assessed ciliary beating frequency (CBF), mucociliary transport velocity (MCTV), and mucus transportability (MT). There was no significant difference for CBF regarding dose (P = .089) or treatment duration (P = .175). MCTV values of 0.60 ± 0.14 in group P1, 0.59 ± 0.13 in group P2, 0.51 ± 0.19 in group P3, and 0.61 ± 0.08 Group Sal, showed P3 to significantly differ from P1 (P = .048) and Sal (P = .007) groups. Regardless of the prednisone dose, all groups displayed impaired MT compared with the Sal group: P1 (P = .02); P2 (P = .02) P3 (P = .03). There was no interaction between the therapy and the treatment time for CBF (P = .10), MCTV (P = .71), and MT (P = .64). Prednisone reduced the transportability of mucus even when administered at low doses; however, this change was not sufficient to alter the mucociliary clearance. Only high doses of prednisone impaired mucociliary clearance.
Authors:
K A Oliveira-Braga; N A Nepomuceno; A T Correia; F B Jatene; P M Pêgo-Fernandes
Related Documents :
20713326 - Effects of enrofloxacin, flunixin meglumine and dexamethasone on disseminated intravasc...
11280646 - Effects of magnesium sulfate on tissue lactate and malondialdehyde levels in experiment...
9286956 - Additional hypotensive effect of endothelin-1 receptor antagonism in hypertensive dogs ...
24904956 - Seamless phase i/ii adaptive design for oncology trials of molecularly targeted agents.
3240766 - The effects of once-daily dosing with ranitidine and cimetidine on theophylline pharmac...
9040496 - Isoflurane and propofol block neurotoxicity caused by mk-801 in the rat posterior cingu...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  44     ISSN:  1873-2623     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2486-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Laboratory of Thoracic Surgery Research, Heart Institute (InCor), Hospital das Clínicas, São Paulo, Brazil. Electronic address: kariandri@usp.br.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The impact of tacrolimus as rescue therapy in children using a double immunosuppressive regimen afte...
Next Document:  Protective effects of human amniotic fluid stem cells in a model of aorta allograft vasculopathy in ...