Document Detail


Effects of preconceptional paternal drug exposure on birth outcomes: cohort study of 340 000 pregnancies using Norwegian population-based databases.
MedLine Citation:
PMID:  22897396     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: We aimed to explore associations between drugs dispensed to the father prior to conception and pregnancy outcomes, such as pre-term birth, perinatal mortality, foetal growth retardation and birth defects.
METHODS: In this cohort study, two population-based registries, the Medical Birth Registry of Norway and the Norwegian Prescription Database, were linked. The study cohort consisted of 340 000 pregnancies in 2004-10. The association between specific drugs dispensed to the fathers during the last 3 months prior to conception and pregnancy outcomes was explored by estimating odds ratios (ORs) using multivariate logistic regression.
RESULTS: About one quarter (26%) of the fathers were dispensed at least one drug during the last 3 months prior to conception and 1.3% were dispensed at least one drug requiring special attention. Overall, the odds of different adverse pregnancy outcomes were not increased when the father had been dispensed drugs, i.e. the OR and 95% confidence intervals (CIs) for any birth defect when the fathers had been dispensed any drug were 0.99 (0.94, 1.0). When the fathers had been dispensed diazepam we found increased risk of perinatal mortality and growth retardation, with OR and 95% CIs of 2.2 (1.2, 3.9) and 1.4 (1.2, 1.6), respectively.
CONCLUSIONS: Large studies are necessary to reveal increased risk of rare outcomes as specific birth defects. Our study did not indicate that paternal drug exposure is an important risk factor for adverse pregnancy outcomes.
Authors:
Anders Engeland; Tone Bjørge; Anne Kjersti Daltveit; Svetlana Skurtveit; Siri Vangen; Stein Emil Vollset; Kari Furu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  75     ISSN:  1365-2125     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-18     Completed Date:  2013-09-20     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1134-41     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / chemically induced,  epidemiology*
Adult
Cohort Studies
Congenital Abnormalities / epidemiology*
Databases, Factual
Fathers*
Female
Fetal Growth Retardation / epidemiology*
Humans
Infant, Low Birth Weight*
Infant, Newborn
Male
Middle Aged
Norway / epidemiology
Perinatal Mortality*
Premature Birth / chemically induced,  epidemiology*
Prescription Drugs / adverse effects*
Chemical
Reg. No./Substance:
0/Prescription Drugs
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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