Document Detail

Effects of prebiotics on mineral metabolism.
MedLine Citation:
PMID:  11157358     Owner:  NLM     Status:  MEDLINE    
Nondigestible oligosaccharides (NDOs) have been found to stimulate absorption of several minerals and to improve mineralization of bone. Hence, these substances are potential ingredients for "functional foods." In addition to a nutritional effect, functional foods have physiologic and psychological benefits that result in improved health or reduced risk of chronic disease. Most of the scientific evidence for the functional effects of NDOs is based on animal experiments in which NDOs increased the availability of calcium, magnesium, zinc, and iron. This stimulatory effect of some NDOs is assumed to be mainly due to their prebiotic character. A prebiotic is defined as a substrate or food ingredient that is nondigestible for the host but is fermented selectively by some of the intestinal microflora. Thus, it stimulates the growth and activity of bacteria with beneficial consequences for the host's health. Recently, these findings were confirmed in human studies for some NDOs. The effects seem to be specific for the type of carbohydrate and are likely related to the rate of fermentation by the intestinal flora and appear to depend on the ingested dose. Contradictory results of the effect of prebiotics in literature may be due to the experimental design because the effect of NDOs depends on the dose, the time of administration, the content of calcium in the diet, the part of the skeleton investigated, and the age of the subjects studied.
K E Scholz-Ahrens; G Schaafsma; E G van den Heuvel; J Schrezenmeir
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  73     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-03-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  459S-464S     Citation Subset:  AIM; IM    
Institute of Physiology and Biochemistry of Nutrition, Federal Dairy Research Center, Kiel, Germany.
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MeSH Terms
Absorption / drug effects
Biological Availability
Calcification, Physiologic / drug effects*
Calcium, Dietary / pharmacokinetics*
Dose-Response Relationship, Drug
Health Food
Intestines / microbiology*
Iron / pharmacokinetics
Magnesium / metabolism
Minerals / metabolism*
Models, Animal
Oligosaccharides / pharmacology*
Phosphorus / metabolism
Time Factors
Zinc / pharmacokinetics
Reg. No./Substance:
0/Calcium, Dietary; 0/Minerals; 0/Oligosaccharides; 7439-89-6/Iron; 7439-95-4/Magnesium; 7440-66-6/Zinc; 7723-14-0/Phosphorus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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