Document Detail


Effects of pre- and postweaning undernutrition on polyphosphoinositide pools in rat kidney.
MedLine Citation:
PMID:  3010027     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of undernutrition on polyphosphoinositide levels in rat kidneys removed and frozen immediately after animal death or 10 min later were determined. Weanling (21-day-old) rats of dams fed a 5 or 22% protein diet and litters fed either normal or protein-deficient diets for an additional six wk were used. Nutritional deprivation lowered phosphatidylinositol-4-phosphate (PtdIns4P) preferentially (35-40%) but preserved phosphatidylinositol-4,5-bisphosphate (PtdIns4,5P2) at weaning. This effect was not completely reversed in animals nutritionally rehabilitated after weaning. Postweaning protein deficiency did not reduce the levels of these lipids. Postmortem loss was the same for all five groups, minimal for PtdIns4P and about one-third for PtdIns4,5P2.
Authors:
U S Ananth; C V Ramakrishnan; G Hauser
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lipids     Volume:  21     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-05-30     Completed Date:  1986-05-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  226-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging
Animals
Animals, Suckling
Body Weight
Kidney / anatomy & histology,  growth & development,  metabolism*
Nutrition Disorders / metabolism*
Organ Size
Phosphatidylinositol Phosphates
Phosphatidylinositols / metabolism*
Postmortem Changes
Rats
Weaning
Grant Support
ID/Acronym/Agency:
NS06399/NS/NINDS NIH HHS; NS19047/NS/NINDS NIH HHS; RR05484/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Phosphatidylinositol Phosphates; 0/Phosphatidylinositols

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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