Document Detail


Effects of pre-meal drinks with protein and amino acids on glycemic and metabolic responses at a subsequent composite meal.
MedLine Citation:
PMID:  23028596     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Whey proteins have insulinogenic properties and the effect appears to originate from a specific postprandial plasma amino acid pattern. The insulinogenic effect can be mimicked by a specific mixture of the five amino acids iso, leu, lys, thr and val.
OBJECTIVE: The objective was to evaluate the efficacy of pre-meal boluses of whey or soy protein with or without added amino acids on glycaemia, insulinemia as well as on plasma responses of incretins and amino acids at a subsequent composite meal. Additionally, plasma ghrelin and subjective appetite responses were studied.
DESIGN: In randomized order, fourteen healthy volunteers were served a standardized composite ham sandwich meal with either water provided (250 ml) during the time course of the meal, or different pre-meal protein drinks (PMPD) (100 ml provided as a bolus) with additional water (150 ml) served to the meal. The PMPDs contained 9 g protein and were based on either whey or soy protein isolates, with or without addition of the five amino acids (iso, leu, lys, thr and val) or the five amino acids + arg.
RESULTS: All PMPD meals significantly reduced incremental area for plasma glucose response (iAUC) during the first 60 min. All whey based PMPD meals displayed lower glycemic indices compared to the reference meal. There were no significant differences for the insulinemic indices. The early insulin response (iAUC 0-15 min) correlated positively to plasma amino acids, GIP and GLP-1 as well as to the glycemic profile. Additionally, inverse correlations were found between insulin iAUC 0-15 min and the glucose peak.
CONCLUSION: The data suggests that a pre-meal drink containing specific proteins/amino acids significantly reduces postprandial glycemia following a composite meal, in absence of elevated insulinemic excursions. An early phase insulinemic response induced by plasma amino acids and incretins appears to mediate the effect.
TRIAL REGISTRATION: ClinicalTrials.gov NCT01586780<NCT01586780>
Authors:
Ulrika J Gunnerud; Cornelia Heinzle; Jens J Holst; Elin M Östman; Inger M E Björck
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-09-19
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-03-06     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e44731     Citation Subset:  IM    
Affiliation:
Department of Applied Nutrition and Food Chemistry, Lund University, Lund, Sweden. ulrika.gunnerud@appliednutrition.lth.se
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT01586780
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MeSH Terms
Descriptor/Qualifier:
Adult
Amino Acids / administration & dosage*,  blood*
Blood Glucose / metabolism*
Female
Gastric Inhibitory Polypeptide / blood
Glucagon-Like Peptide 1 / blood
Humans
Insulin / blood*
Male
Meals*
Milk Proteins / administration & dosage*
Soybean Proteins / administration & dosage*
Young Adult
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Blood Glucose; 0/Insulin; 0/Milk Proteins; 0/Soybean Proteins; 0/whey protein; 59392-49-3/Gastric Inhibitory Polypeptide; 89750-14-1/Glucagon-Like Peptide 1
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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