Document Detail


Effects of pre-hospital Clopidogrel administration on early and late residual platelet reactivity in ST-segment elevation myocardial infarction patients undergoing primary intervention.
MedLine Citation:
PMID:  23114060     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Calling on prior experience with patients affected by non-ST-segment elevation acute coronary syndromes, as well as from patients undergoing coronary stenting, clopidogrel, given as soon as possible at a loading dose of 300 or preferably 600 mg is recommended for patients with ST-segment elevation myocardial infarction undergoing mechanical treatment[1,2]. One single small study has so far evaluated the pharmacokinetic effect of 600 mg loading dose of clopidogrel in 11 STEMI patients. The effect of clopidogrel was negligible at 4 hours and it persisted to be suboptimal when compared with that achieved in healthy controls at 6 hours after administration[3]. © 2012 International Society on Thrombosis and Haemostasis.
Authors:
S Biscaglia; M Tebaldi; P Vranckx; G Campo; M Valgimigli
Publication Detail:
Type:  LETTER     Date:  2012-10-31
Journal Detail:
Title:  Journal of thrombosis and haemostasis : JTH     Volume:  -     ISSN:  1538-7836     ISO Abbreviation:  J. Thromb. Haemost.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101170508     Medline TA:  J Thromb Haemost     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 International Society on Thrombosis and Haemostasis.
Affiliation:
Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna, Ferrara, Italy Department of Cardiac Intensive Care & Interventional Cardiology, Hartcentrum, Hasselt, Belgium Cardiovascular Research Centre, Salvatore Maugeri Foundation, IRCCS Ferrara (FE), Italy.
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