| Effects of pre-hospital Clopidogrel administration on early and late residual platelet reactivity in ST-segment elevation myocardial infarction patients undergoing primary intervention. | |
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MedLine Citation:
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PMID: 23114060 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Calling on prior experience with patients affected by non-ST-segment elevation acute coronary syndromes, as well as from patients undergoing coronary stenting, clopidogrel, given as soon as possible at a loading dose of 300 or preferably 600 mg is recommended for patients with ST-segment elevation myocardial infarction undergoing mechanical treatment[1,2]. One single small study has so far evaluated the pharmacokinetic effect of 600 mg loading dose of clopidogrel in 11 STEMI patients. The effect of clopidogrel was negligible at 4 hours and it persisted to be suboptimal when compared with that achieved in healthy controls at 6 hours after administration[3]. © 2012 International Society on Thrombosis and Haemostasis. |
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Authors:
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S Biscaglia; M Tebaldi; P Vranckx; G Campo; M Valgimigli |
Publication Detail:
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Type: LETTER Date: 2012-10-31 |
Journal Detail:
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Title: Journal of thrombosis and haemostasis : JTH Volume: - ISSN: 1538-7836 ISO Abbreviation: J. Thromb. Haemost. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-11-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101170508 Medline TA: J Thromb Haemost Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 International Society on Thrombosis and Haemostasis. |
Affiliation:
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Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna, Ferrara, Italy Department of Cardiac Intensive Care & Interventional Cardiology, Hartcentrum, Hasselt, Belgium Cardiovascular Research Centre, Salvatore Maugeri Foundation, IRCCS Ferrara (FE), Italy. |
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